DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and ltb4r2a

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_017212293.2	Gene:	ltb4r2a / 100535026	ZFINID:	ZDB-GENE-140106-272	Length:	402	Species:	Danio rerio

Alignment Length:	351	Identity:	78/351 - (22%)
Similarity:	148/351 - (42%)	Gaps:	81/351 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PMAEQVPEHVMD--HAPQLSRS-------------GLLKVYVLAVMALFSLLGNLLTIWNIYKTR 147
            |||.|.|.....  |...||.:             .:....:|:::.|..:.||:..:|:|. .|
Zfish    20 PMALQSPSFYTSTLHPTNLSNNTSGRGSIVDNKGGAITGAAILSLVFLLGVPGNVFIMWSIL-AR 83

  Fly   148 ISRRNSRHTWSAIYSLMFHLSIAD---VLVTWFCIIGEAAWCYTVQ--WLANELTCKLVKLFQMF 207
            ..||      |....|:.:|:.||   :|:|.|.::      |.||  |:.:...||::......
Zfish    84 ARRR------SITTLLILNLAFADGFLMLLTPFFMV------YLVQRSWVFSLALCKVLYYLCCA 136

  Fly   208 SLYLSTYVLVLIGVDRWIAVKYPMK--SLNMAKRCHRLLGGTYILSLVLSLPQFFIFHVARGPFV 270
            ::|.|.::::|:.:.|.:|:.:|.:  :....|...|:|.|.::|:|.||.|.....::......
Zfish   137 NMYASIFMIMLMSLHRLVAIVWPKRVGAKTERKMLTRVLVGLWVLALGLSAPVLAFRNILSDSKK 201

  Fly   271 EEFYQC-VTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSSEKMFQGSKLANYS 334
            .|.:.| ..|.  ...::...|:..||: .||||..::.|:|....|.|..:.
Zfish   202 PEKFVCDCIHP--ETQYEVMQYSMETLL-GFLLPYGVIIGSYTCILRRIRKTR------------ 251

  Fly   335 TAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYV--MMIMFMFLNPD-----KRLGD- 391
                          .:.:::|.::.:||::.|.:.|.||::  |:.:...|.|:     .||.:
Zfish   252 --------------FRRRIRSEKLILVIVVTFGLFWLPYHIINMVQVTAALLPEGSAAKHRLQEI 302

  Fly   392 -----DLQDAIFFFGMSNSLVNPLIY 412
                 .|...:.|.   :|.:||::|
Zfish   303 RANMRALTSTVAFV---SSCINPVLY 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	37/139 (27%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	67/297 (23%)
ltb4r2a	XP_017212293.2	7tm_GPCRs	56..337	CDD:333717	70/315 (22%)
		TM helix 1	58..82	CDD:320095	6/24 (25%)
		TM helix 2	91..112	CDD:320095	7/20 (35%)
		TM helix 3	128..150	CDD:320095	4/21 (19%)
		TM helix 4	173..189	CDD:320095	7/15 (47%)
		TM helix 5	218..241	CDD:320095	8/23 (35%)
		TM helix 6	256..281	CDD:320095	7/24 (29%)
		TM helix 7	304..329	CDD:320095	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100