DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrzR and gnrhr

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001107549.1	Gene:	gnrhr / 100135417	XenbaseID:	XB-GENE-5753573	Length:	410	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	115/390 - (29%)
Similarity:	194/390 - (49%)	Gaps:	49/390 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 PQLSRSGLLKVYVLAVMALFSLLGNLLTIWNI-YKTRISRRNSRHTWSAIYSLMFHLSIADVLVT 175
            |..|.:..::|.:..::.:||...|:..:|.| ||.|..        |.|..|:.:|..||:.:|
Frog    41 PIFSTAAKIRVAITCILFVFSTCFNVAALWTITYKYRKK--------SHIRILIINLVAADLFIT 97

  Fly   176 WFCIIGEAAWCYTVQWLANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRC 240
            ...:..:|.|..|:||.|.:|.|:::...::.::|.|.:|.|:|.:||..||..|:...:..|:.
Frog    98 LVVMPLDAVWNVTLQWYAGDLACRVLMFLKLAAMYSSAFVTVVISLDRQAAVLNPLGIRDAKKKN 162

  Fly   241 HRLLGGTYILSLVLSLPQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLC 305
            ..:|...:.||.:|::||.|:||.........|.||.|.|.:.|.|||.:|..||....|||||.
Frog   163 KIMLCVAWSLSYLLAIPQLFVFHTVSRSEPVHFVQCATVGSFQAHWQETIYNMFTFFCLFLLPLL 227

  Fly   306 ILFGTYMSTFRTISSSEKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICW 370
            |:...|......|  :.||    |.|..|:.::..:.:... |.:|:|::|::|:||::.|::||
Frog   228 IMVFCYARILMEI--THKM----KAACVSSKEIDLRRSSNN-IPRARMRTLKMSLVIVLTFIVCW 285

  Fly   371 TPYYVMMIMFMFLNPD----KRLGDDLQDAIFFFGMSNSLVNPLIYGAF---------HLCPGKG 422
            ||||::.|.:.| :|:    :::...|...:|.||:.|:.::|:|||.|         .:|
Frog   286 TPYYLLGIWYWF-SPEMLTKEKVPPSLSHILFLFGLLNTCLDPIIYGLFTIHFRREIRRVC---- 345

  Fly   423 GKSSGGGGNNNAYSLNRGD---SQRTPSMLTAV--------TQVDGTG---GSSRQMRAFRQQSY 473
             :.:..|.:::..||..|.   |..|..|..||        .:|.|.|   |...|.|....:|:
Frog   346 -RCAAQGKDHDTASLGTGSFRISTTTVPMKRAVLGGSGKLELEVTGYGLHSGKCEQCRGKIMESF 409

Fly 474 473
Frog 410 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	40/133 (30%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	89/281 (32%)
gnrhr	NP_001107549.1	7tmA_GnRHR_vertebrate	48..341	CDD:320505	96/308 (31%)
		TM helix 1	50..74	CDD:320505	6/23 (26%)
		TM helix 2	83..106	CDD:320505	5/22 (23%)
		TM helix 3	121..143	CDD:320505	5/21 (24%)
		TM helix 4	164..180	CDD:320505	4/15 (27%)
		TM helix 5	211..234	CDD:320505	9/22 (41%)
		TM helix 6	271..293	CDD:320505	11/21 (52%)
		TM helix 7	309..334	CDD:320505	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920