DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrzR and gnrhr2

DIOPT Version :9

Sequence 1:	NP_001261755.1	Gene:	CrzR / 39409	FlyBaseID:	FBgn0036278	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001107547.1	Gene:	gnrhr2 / 100135415	XenbaseID:	XB-GENE-5867415	Length:	410	Species:	Xenopus tropicalis

Alignment Length:	439	Identity:	125/439 - (28%)
Similarity:	210/439 - (47%)	Gaps:	63/439 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 MATDISNLSVSTTPLPAYAISNSSSLAHTNSRHEAPPMAEQVPEHVMDHAPQLSRSGLLKVYVLA 126
            |.|:: |::..|..:....:...||.. |..|:.:.....|.|..:    |..|.:...:|.:..
Frog     1 MPTEM-NITKDTDSITCNNVLWLSSYC-TMDRNTSSAAEAQNPFQL----PTFSPAAKARVIITF 59

  Fly   127 VMALFSLLGNLLTIWNIYKTRISRRNSRHTWSAIYSLMFHLSIADVLVTWFCIIGEAAWCYTVQW 191
            |:...|...||..:|  ..|..||:...|    :..|:.:|:.||:|||:..:..:|.|..||||
Frog    60 VIFALSAFCNLAVVW--ASTNTSRKKRSH----VRILILNLTTADLLVTFIVMPLDAIWNITVQW 118

  Fly   192 LANELTCKLVKLFQMFSLYLSTYVLVLIGVDRWIAVKYPMKSLNMAKRCHRLLGGTYILSLVLSL 256
            .|.:|.|:::...::.|:|...:|.|:|.:||..|:..|:......||...:|...:::|::|||
Frog   119 QAGDLACRILMFLKLLSMYSCAFVTVVISIDRQSAILNPLGISEAKKRNKIMLSVAWLMSILLSL 183

  Fly   257 PQFFIFHVARGPFVEEFYQCVTHGFYTADWQEQMYATFTLVFTFLLPLCILFGTYMSTFRTISSS 321
            ||.|:||.......:.|.||.|.|.:...|||.:|...:.|..|||||.|:...|....  |..|
Frog   184 PQLFLFHTVTITEPQNFTQCTTRGSFQEHWQETVYNMVSFVCLFLLPLLIMISCYSRIL--IEIS 246

  Fly   322 EKMFQGSKLANYSTAKLPTQTNRQRLIHKAKMKSLRISVVIIIAFLICWTPYYVMMIMFMFLNP- 385
            .:|.:|:    .|:.::..:.::.. |.||:|::|::|:||:.:|:|||||||::.:.:.|...
Frog   247 RRMSKGA----LSSKEVYLRRSKNN-IPKARMRTLKMSIVIVSSFIICWTPYYLLGLWYWFYPEA 306

  Fly   386 -DKRLGDDLQDAIFFFGMSNSLVNPLIYGAF--HLCPG-----KGGKSSGGGGNNNAYSLNRGDS 442
             ::|:...|...:|.||:.|:.::|:.||.|  |...|     :||::|              |.
Frog   307 MEERVSQSLTHILFIFGLVNACLDPITYGLFTIHFRKGLHRYCRGGRAS--------------DL 357

  Fly   443 QRTPSMLTAVTQVDGTGGSSRQMRAFR------------QQSYYRSSSN 479
            ..:.|:         ||.....|.:||            .|.|..||:|
Frog   358 DTSSSV---------TGSFRCSMSSFRAKKIVLNQELQVMQGYNGSSNN 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrzR	NP_001261755.1	7tm_4	127..>260	CDD:304433	43/132 (33%)
CrzR	NP_001261755.1	7tm_1	135..412	CDD:278431	90/278 (32%)
gnrhr2	NP_001107547.1	TM helix 5	216..239	CDD:320505	8/22 (36%)
		TM helix 6	276..298	CDD:320505	12/21 (57%)
		TM helix 7	313..338	CDD:320505	8/24 (33%)
		7tmA_GnRHR_vertebrate	52..345	CDD:320505	97/305 (32%)
		TM helix 1	54..78	CDD:320505	6/25 (24%)
		TM helix 2	88..111	CDD:320505	7/22 (32%)
		TM helix 3	126..148	CDD:320505	5/21 (24%)
		TM helix 4	169..185	CDD:320505	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368588at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X690
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920