DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and YOX1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_013685.1	Gene:	YOX1 / 854981	SGDID:	S000004489	Length:	385	Species:	Saccharomyces cerevisiae

Alignment Length:	220	Identity:	54/220 - (24%)
Similarity:	82/220 - (37%)	Gaps:	74/220 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 KRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQN 489
            ||.||  :||:....:|.|::.|.|.::.|..||:...::.:.||:||||:|..:|: ||.|...
Yeast   179 KRRRT--SSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKR-QRIATSK 240

  Fly   490 GGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPD 554
                                                            ||...|.::|  |..|.
Yeast   241 ------------------------------------------------STTIIQTVSP--PSPPL 255

  Fly   555 DYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNN--------LELQSTSSS--GNQHSHSHSN 609
            |..|....|...:|:..|||:..:   .:.|..|.|        |..:|::.|  .:|....|.|
Yeast   256 DVHATPLASRVKADILRDGSSCSR---SSSSSPLENTPPRPHHSLNRRSSTPSIKRSQALTFHLN 317

  Fly   610 PH-----DMLANLN---NSLINPID 626
            |.     .:..:.|   |.|||.||
Yeast   318 PQKKTLTPVKTSPNSRVNKLINSID 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	18/52 (35%)
YOX1	NP_013685.1	COG5576	126..267	CDD:227863	33/140 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030