DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmx1a and lpp

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_012818600.1	Gene:	lpp / 779875	XenbaseID:	XB-GENE-951633	Length:	614	Species:	Xenopus tropicalis

Alignment Length:	547	Identity:	105/547 - (19%)
Similarity:	160/547 - (29%)	Gaps:	202/547 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PMPT--NLNP---VGGSLYSLQQNHGGARFLDNPNPGSMTASSGNSL--HLSNSNNNLPTSISGN 63
            ||||  ||.|   ...:::::|.|.||....:..:.......|..|:  .|.||:...|.:..|.
Frog    84 PMPTLGNLPPPPVPDEAMFNVQINTGGKTIEERRSSLDAEIDSLTSILADLENSSPYKPRTPQGP 148

  Fly    64 NS-------PTATASLTGQHQQHQQQQHQQQQQHPHQQHQQHQQQHAASTTPVPINS------CP 115
            .|       |:|...:||    |::.....|......:....:.|..:::.|.|..|      .|
Frog   149 GSNTGTLTHPSAGTPVTG----HKRMIIPNQPPLTATKKSATKPQPQSTSQPAPAGSPGAQRPQP 209

  Fly   116 TPTGHSPLSSSSSNSNHNNNNNNNN----------GGSSSNNLHSACNTLTAAAVAAASAAAVAA 170
            .|   :|.:::|:.|....|....:          |.....|...|.|...|.....:......|
Frog   210 VP---APYATASTPSRPTFNVQVKSAQPSPHFVPPGPQLGQNYSPAPNQYYAPQPTRSPGPMQYA 271

  Fly   171 PSPA------------------------------------------GTSVATSQLGG-------- 185
            |.|.                                          |:.|..:|.||
Frog   272 PQPRGQEYIPPPPARYVEPGYGYSQGNQSKYQDPYYQSVQGYGGRNGSEVPYTQQGGWKPEPAYS 336

  Fly   186 ---AVAAAIAAAAAAAAAATTPTS------------------TGP--AATGS------------- 214
               ||....|.....|.:...|.:                  .||  |...|
Frog   337 PIPAVGQQPAVGQQPAGSYQPPNTKKTYITDPPYIPPPPPQPKGPYLAQASSLRPEDELERLTKK 401

  Fly   215 --------------GNANGSGNGNGNGNGNGNGNGNGNGGGAATASAAAASKLSADCSGRTEVGH 265
                          |..:..|.         |..|.|.|                 |:...:|.|
Frog   402 MLYDMENPPSEEYFGRCSRCGE---------NVVGEGTG-----------------CTAMDQVFH 440

  Fly   266 IKC------------------EK----------NFELCEGCGQKIHDRFLMNVGDANWHEQCLAC 302
            ::|                  ||          ..|.|..|.:.|.:|.|...|.| :|..|..|
Frog   441 VECFTCMTCNSKLRGQPFYAVEKKAFCEPCYIRTLEKCSVCAKPIMERILRATGKA-YHPHCFTC 504

  Fly   303 CYCGMQLHHTCYV--RNSKLYCKMDYDRLFGVKCSSCCHAILP---QELVMRPIP-NFVFHLPCF 361
            ..|...|....:.  .:.:::|..|:.:.|..:||.|...|:|   ||..:|.:. :..||:.|:
Frog   505 VVCFRSLDGIPFTVDASGQIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVQCY 569

  Fly   362 VCYACRLPLQKGEQ---FMLRDGQLFC 385
            .|..|...|.:||.   :.| ||.:.|
Frog   570 RCEDCGSLLSEGENQGCYPL-DGHILC 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	14/53 (26%)
		LIM	333..388	CDD:295319	20/60 (33%)
		Homeobox	427..480	CDD:278475
lpp	XP_012818600.1	PHA03247	<4..358	CDD:223021	52/280 (19%)
		PRK10263	<171..>341	CDD:236669	24/172 (14%)
		LIM1_TRIP6	418..471	CDD:188736	11/78 (14%)
		LIM	478..537	CDD:413332	15/59 (25%)
		LIM3_TRIP6	538..603	CDD:188820	20/59 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910