DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and zyx

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001072265.1	Gene:	zyx / 779718	XenbaseID:	XB-GENE-6453993	Length:	674	Species:	Xenopus tropicalis

Alignment Length:	153	Identity:	47/153 - (30%)
Similarity:	64/153 - (41%)	Gaps:	21/153 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 SKLSADCSGR---TEVGHIKCEK----NFELCEGCGQKIHDRFLMNVGDANWHEQCLAC--CYCG 306
            ||......|:   ...|...||:    ..|.|..|.:||.:|.|..:|.| :|..|..|  |.|.
Frog   512 SKCEQQLQGQQYYESAGKPLCEECYQDTLECCAVCEKKITERLLRAIGQA-YHPSCFTCAVCKCS 575

  Fly   307 MQLHHTCYVRNSKL-YCKMDYDRLFGVKCSSCCHAILPQ----ELVMRPIPNFVFHLPCFVCYAC 366
            :| .....|.::|| :|..||.|.:..:|:.|...|.|:    |.|........||:.|:.|..|
Frog   576 LQ-GEPFIVDDNKLPHCVSDYHRRYAPRCTVCGDPIAPEPGRDETVRVVALEKNFHMMCYKCEDC 639

  Fly   367 RLPL----QKGEQFMLRDGQLFC 385
            ..||    ..|..|.| ||.:.|
Frog   640 GCPLSIEADDGGCFPL-DGHVLC 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	19/54 (35%)
		LIM	333..388	CDD:295319	19/61 (31%)
		Homeobox	427..480	CDD:278475
zyx	NP_001072265.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..447
		LIM1_Zyxin	449..536	CDD:188735	6/23 (26%)
		LIM	543..602	CDD:295319	21/60 (35%)
		LIM3_Zyxin	603..669	CDD:188819	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910