DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and ZYX

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001010972.1	Gene:	ZYX / 7791	HGNCID:	13200	Length:	572	Species:	Homo sapiens

Alignment Length:	402	Identity:	77/402 - (19%)
Similarity:	119/402 - (29%)	Gaps:	123/402 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EFYPMPTNLNPVGGSLYSLQQNHGGARFLDNPNPGSMTASSGNSLHLSNSNNNL--PTSISGNNS 65
            :|.|:.....||....                :||:...|.      |..|..|  |.::|....
Human   265 KFSPVTPKFTPVASKF----------------SPGAPGGSG------SQPNQKLGHPEALSAGTG 307

  Fly    66 PTATASLTGQHQQHQQQQHQQQQQHPHQQHQQHQQQHAASTTPVPINSCPTPTGHSPLSSSSSNS 130
            .....|.|  :.|.:::...|::|||.....|:|.|..:...|.|:.................:.
Human   308 SPQPPSFT--YAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDM 370

  Fly   131 NHNNNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAAA 195
            .|                                        |...:||.::|.|.....:|.|.
Human   371 EH----------------------------------------PQRQNVAVNELCGRCHQPLARAQ 395

  Fly   196 AAAAAATTPTSTGPAATGSGNANGSGNGNGNGNGNGNGNGNGNGGGAATASAAAASKLSADCSGR 260
            .|..|.                                      |.....:.....:.:....|:
Human   396 PAVRAL--------------------------------------GQLFHIACFTCHQCAQQLQGQ 422

  Fly   261 ---TEVGHIKCE----KNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYV--R 316
               :..|...||    ...|.|..||:.|.||.|...|.| :|..|..|..|...|..|.::  :
Human   423 QFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKA-YHPHCFTCVVCARPLEGTSFIVDQ 486

  Fly   317 NSKLYCKMDYDRLFGVKCSSCCHAILPQ----ELVMRPIPNFVFHLPCFVCYACRLPL----QKG 373
            .::.:|..||.:.:..:||.|...|:|:    |.|.....:..||:.|:.|..|..||    ...
Human   487 ANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDN 551

  Fly   374 EQFMLRDGQLFC 385
            ..|.| ||.:.|
Human   552 GCFPL-DGHVLC 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	17/53 (32%)
		LIM	333..388	CDD:295319	19/61 (31%)
		Homeobox	427..480	CDD:278475
ZYX	NP_001010972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..351		23/109 (21%)
		PAT1	<201..>365	CDD:330585	24/123 (20%)
		LIM1_Zyxin	351..437	CDD:188735	15/163 (9%)
		LIM	444..503	CDD:295319	18/59 (31%)
		LIM3_Zyxin	504..570	CDD:188819	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910