DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Limk1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_113915.2	Gene:	Limk1 / 65172	RGDID:	62055	Length:	647	Species:	Rattus norvegicus

Alignment Length:	133	Identity:	43/133 - (32%)
Similarity:	65/133 - (48%)	Gaps:	10/133 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 CSGRTE-VGHIKCEKNFEL--CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNS 318
            |:.|.| :|    |:..||  |..|.|.|:|...:...:|:||..|..||.|...|.|..|.::.
  Rat     8 CTWREERMG----EEGSELPVCASCSQSIYDGQYLQALNADWHADCFRCCECSTSLSHQYYEKDG 68

  Fly   319 KLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQF-MLRDGQ 382
            :|:||.||...:|..|..|...| .:.||| ......:|..||:|.||...:..|:.: ::...:
  Rat    69 QLFCKKDYWARYGESCHGCSEHI-TKGLVM-VAGELKYHPECFICLACGNFIGDGDTYTLVEHSK 131

  Fly   383 LFC 385
            |:|
  Rat   132 LYC 134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	19/51 (37%)
		LIM	333..388	CDD:295319	15/54 (28%)
		Homeobox	427..480	CDD:278475
Limk1	NP_113915.2	LIM1_LIMK1	5..77	CDD:188846	26/72 (36%)
		LIM2_LIMK1	84..138	CDD:188848	15/53 (28%)
		PDZ	165..255	CDD:278991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..316
		TyrKc	342..604	CDD:197581
		STKc_LIMK1	345..611	CDD:271123
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910