Protein Alignment Lmx1a and NKX2-4

DIOPT Version :9

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 82/355 - (23%)
• Similarity: 102/355 - (28%)
• Gaps: 160/355 - (45%)

  Fly   164 SAAAVAAPSPAGTSVATSQLG----------GAVAAAIAAAAAAAAAATTPTSTGPAATGSGNAN 218
            :|||..||.|..:|.|.:..|          .|.|||.|||||||||||.....|.:....| |.
Human    44 AAAAYRAPPPGPSSQAATVAGMQPSHAMAGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHG-AM 107

  Fly   219 GSGNGNGNGN-GNGNGNGNGNGGGAATA--------SAAAASKLSADCSGRTEVGHIKCEKNFEL 274
            ||....|.|| |......:|..|||||.        ..::.|:.....:|..
Human   108 GSYCNGGLGNMGELPAYTDGMRGGAATGWYGANPDPRYSSISRFMGPSAGVN------------- 159

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCH 339
            ..|.|.      |..:.||                                      .|.....|
Human   160 VAGMGS------LTGIADA--------------------------------------AKSLGPLH 180

  Fly   340 AILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHC 404
            |                                                        |||||
Human   181 A--------------------------------------------------------AAAAA--- 186

  Fly   405 GFVGLDEEDLLRPRDGRRGPKRPRTILTSQ-QRKQFKASFDQSPKPCRKVREALAKDTGLSVRVV 468
                              .|:|.|.:|.|| |..:.:..|.|........||.||....|:...|
Human   187 ------------------APRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQV 233

  Fly   469 QVWFQNQRAKMK-----KIQRKAKQNGGSG 493
            ::||||.|.|||     |..::.:|.||.|
Human   234 KIWFQNHRYKMKRQAKDKAAQQLQQEGGLG 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	5/51 (10%)
		LIM	333..388	CDD:295319	3/54 (6%)
		Homeobox	427..480	CDD:278475	19/53 (36%)
NKX2-4	NP_149416.1	Homeobox	192..245	CDD:278475	19/52 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		5/18 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910