DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and LHX5

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_071758.1	Gene:	LHX5 / 64211	HGNCID:	14216	Length:	402	Species:	Homo sapiens

Alignment Length:	395	Identity:	122/395 - (30%)
Similarity:	167/395 - (42%)	Gaps:	105/395 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCH 339
            |.||.:.|.||||:||.|..||.:|:.||.|...|...|:.|..|||||.|:.|.||.||:.|..
Human     5 CAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQ 69

  Fly   340 AILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDL-----EKEMFLAAA 399
            .|.|.:|| |...:.||||.||.|..|...|..||:..:.|...|..:.|.     .||..|.:.
Human    70 GISPSDLV-RKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYLSSSSLKEGSLNSV 133

  Fly   400 AAQHCGFVGLDEEDLLR--PR------------------DGRRGPKR--PRTILTSQQRKQFKAS 442
            ::.....:..|.:|.|:  |:                  :...|.||  |||.:.::|.:..||:
Human   134 SSCTDRSLSPDLQDALQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAA 198

  Fly   443 FDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGS----GSGRGTG 503
            |..:|||.|.:||.||::|||::||:||||||:|:|    :|:.||....|...    .|.|.
Human   199 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSK----ERRMKQLSALGARRHAFFRSPRR-- 257

  Fly   504 NSSATDDKDTNDKEDKCVKQELGG--DSSGYLGGLDSTFASQPLNPNLPFSPDDYPANSNDSFCS 566
                              .:.|||  |.|..||....|:..            ||         .
Human   258 ------------------MRPLGGRLDESEMLGSTPYTYYG------------DY---------Q 283

  Fly   567 SDLSLDGSNFD--------QLDDDADSLSLNNLELQSTSSSGN----------QHSHSHSNPH-- 611
            .|....|||:|        |....|||..|      :.|..|:          ...|:..||.
Human   284 GDYYAPGSNYDFFAHGPPSQAQSPADSSFL------AASGPGSTPLGALEPPLAGPHAADNPRFT 342

  Fly   612 DMLAN 616
            ||:::
Human   343 DMISH 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	26/51 (51%)
		LIM	333..388	CDD:295319	21/54 (39%)
		Homeobox	427..480	CDD:278475	28/52 (54%)
LHX5	NP_071758.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	25/50 (50%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	20/55 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..186		12/61 (20%)
		Homeobox	183..237	CDD:395001	28/57 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..402		12/56 (21%)
		PHA03378	<301..>392	CDD:223065	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910