DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and PXN

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_016875215.1	Gene:	PXN / 5829	HGNCID:	9718	Length:	1135	Species:	Homo sapiens

Alignment Length:	459	Identity:	96/459 - (20%)
Similarity:	146/459 - (31%)	Gaps:	137/459 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 QHQQQHAA-STTPVPINSCPTPTGHSPLSSSSSNSNHNNNNNNNNGGS-------SSNNLHS-AC 152
            ||:...|| |::|:|.....:|.|.|..:..||.........::.|..       :.:.:.| .|
Human   697 QHRTDAAASSSSPLPSLLASSPLGPSAYTCGSSGVQSAGEEPHDEGVQGPALPIPAPHTMRSVGC 761

  Fly   153 NT----------LTAAAVAAASAAAVAA--PSPAGTSVATSQLGGA-------VAAAIAAAAA-- 196
            .|          :......|......||  |...|.|....|..|.       |...::.:::
Human   762 QTDEDPLFPPMQIQGLEQRADGERCWAAGWPRDGGRSSPGGQDEGGGSWPLEEVVLLVSISSSVQ 826

  Fly   197 --------AAAAATTPTSTGP------------AATGSGNANGSGNGNGNGNGN--GNGNGNGNG 239
                    .||...||:...|            ..|||.:..|.....|:...:  |:...:.|.
Human   827 EGEKYPHPCAARHRTPSLRSPDQPPPCPQFMAQGKTGSSSPPGGPPKPGSQLDSMLGSLQSDLNK 891

  Fly   240 GGAATASAAAASKLSADCSGRT--------------------EVGHIK---------CEKNFE-- 273
            .|.||.:...........:|:.                    |:|...         |||::.
Human   892 LGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 956

  Fly   274 ---LCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGM-----QLHHTCYVRNSKLYCKMDYDRLF 330
               .|..|...|.|: ::...|..||.:...|..||.     ..|.    ::.|.||:.||..:|
Human   957 FSPRCYYCNGPILDK-VVTALDRTWHPEHFFCAQCGAFFGPEGFHE----KDGKAYCRKDYFDMF 1016

  Fly   331 GVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMF 395
            ..||..|..|||...:   ...|.::|..||||..|..|...| .|...|||.:|..|..|:...
Human  1017 APKCGGCARAILENYI---SALNTLWHPECFVCRECFTPFVNG-SFFEHDGQPYCEVHYHERRGS 1077

  Fly   396 LAAAAAQHCGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRK----QFKASF-----------DQ 445
            |.:...              :|..||        .:|:..:|    .|..:|           :|
Human  1078 LCSGCQ--------------KPITGR--------CITAMAKKFHPEHFVCAFCLKQLNKGTFKEQ 1120

  Fly   446 SPKP 449
            :.||
Human  1121 NDKP 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	15/56 (27%)
		LIM	333..388	CDD:295319	20/54 (37%)
		Homeobox	427..480	CDD:278475	7/38 (18%)
PXN	XP_016875215.1	Paxillin	60..259	CDD:281527
		LIM1_Paxillin_like	902..954	CDD:259830	6/51 (12%)
		LIM2_Paxillin	961..1012	CDD:188791	14/55 (25%)
		LIM3_Paxillin_like	1020..1072	CDD:188724	20/55 (36%)
		LIM4_Paxillin	1079..1130	CDD:188795	10/68 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910