DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and nkx2.4a

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001104636.1	Gene:	nkx2.4a / 562300	ZFINID:	ZDB-GENE-030131-6336	Length:	345	Species:	Danio rerio

Alignment Length:	216	Identity:	52/216 - (24%)
Similarity:	75/216 - (34%)	Gaps:	59/216 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 PKRPRTILTSQ-QRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAK 487
            |:|.|.:|.|| |..:.:..|.|........||.||....|:...|::||||.|.|||   |:||
Zfish   159 PRRKRRVLFSQAQVCELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMK---RQAK 220

  Fly   488 QNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFS 552
                                       ||..:.::||         |.|    ..|..:|.....
Zfish   221 ---------------------------DKAAQQLQQE---------GNL----CQQQQSPRRVAV 245

  Fly   553 P----DDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNPHDM 613
            |    |..|       |.:..:....|..|:....:.   ..:.|.::|:|.|||.....|....
Zfish   246 PVLVKDGKP-------CQNGSNTPTPNQQQMQQQQNG---GGVVLPTSSNSMNQHQSQQVNALVQ 300

  Fly   614 LANLNNSLINPIDKLYLMQNS 634
            ..:|.....:| ..|:...||
Zfish   301 AQDLEEMSPSP-PSLHSQMNS 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	19/53 (36%)
nkx2.4a	NP_001104636.1	Homeobox	163..216	CDD:278475	19/52 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910