DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and LMO3

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001230542.1	Gene:	LMO3 / 55885	HGNCID:	6643	Length:	167	Species:	Homo sapiens

Alignment Length:	149	Identity:	51/149 - (34%)
Similarity:	68/149 - (45%)	Gaps:	31/149 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCL--ACCYCGMQLH------------HT----CYVRNSKL- 320
            |.||.:||.||:|:...|..|||.||  |||.|.:..|            ||    |......|
Human    13 CAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEHLKRCGSIYIHAAHTEIGICVTLEWPLP 77

  Fly   321 YCKMDYDR------LFGV--KCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFM 377
            :..:|:.:      ||||  .|::|...|...|:|||...| |:||.||.|..|......|::|.
Human    78 FVIIDFSQQITIAWLFGVTGNCAACSKLIPAFEMVMRAKDN-VYHLDCFACQLCNQRFCVGDKFF 141

  Fly   378 LRDGQLFC---YRHDLEKE 393
            |::..:.|   |...|.||
Human   142 LKNNMILCQTDYEEGLMKE 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	24/70 (34%)
		LIM	333..388	CDD:295319	20/57 (35%)
		Homeobox	427..480	CDD:278475
LMO3	NP_001230542.1	LIM	13..>49	CDD:295319	18/35 (51%)
LMO3	NP_001230542.1	LIM2_LMO1_LMO3	99..153	CDD:188775	19/54 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910