DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and lmx1ba

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001349521.1	Gene:	lmx1ba / 554361	ZFINID:	ZDB-GENE-050114-3	Length:	375	Species:	Danio rerio

Alignment Length:	434	Identity:	160/434 - (36%)
Similarity:	214/434 - (49%)	Gaps:	110/434 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 TASAAAASKLSADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQ 308
            |.:......|.|||:....|           ||||.:.|.||||:.:.|::|||:||.|..|...
Zfish    13 TGAETLGVMLGADCAHHQSV-----------CEGCHRPISDRFLLRMNDSSWHEECLQCSVCQQL 66

  Fly   309 LHHTCYVRNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKG 373
            |..:||.|:.|||||.||.:||..|||.|...|.|.|||||.:.: |:||.||.|..|...|.||
Zfish    67 LTMSCYSRDHKLYCKHDYQQLFATKCSGCLEKISPTELVMRALES-VYHLSCFCCCVCERRLCKG 130

  Fly   374 EQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCGFVGLDEEDL-LRPRDGRRG-------------P 424
            ::|:|::|||.| :.|.|:|..||:.......  ..::||| ::|..|..|             |
Zfish   131 DEFVLKEGQLLC-KTDYEREKDLASPDLSDSD--KSEDEDLDVKPEKGAGGQGKGSDDSKDPRRP 192

  Fly   425 KRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQN 489
            ||||||||:|||:.|||||:.|.||||||||.||.:|||||||||||||||||||||:.|:.:|
Zfish   193 KRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQ- 256

  Fly   490 GGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGD-SSGYLGGLDSTFASQPLNPNLP--- 550
                                      ::::...|.||.| .|..:..|.|::.  ||.|..|
Zfish   257 --------------------------QQEQQNSQRLGQDVMSSRMENLMSSYT--PLAPPPPHAL 293

  Fly   551 ----------------FSPDDYPAN-----SNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLELQ 594
                            .:|...|.:     .|||.           |..:|.|....||::..:.
Zfish   294 VSMESSGYSTDPFQQGLTPPQMPGDHMNPYGNDSI-----------FHDIDSDTSLTSLSDCFMS 347

  Fly   595 STSSSGNQHSHSHSNPHDMLANLNNSLINPIDKLYLMQNSYFSS 638
            ::.:                |.|.:.:.||||:||.||:|||:|
Zfish   348 ASDA----------------AALQSRVGNPIDRLYSMQSSYFTS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	27/51 (53%)
		LIM	333..388	CDD:295319	27/54 (50%)
		Homeobox	427..480	CDD:278475	43/52 (83%)
lmx1ba	NP_001349521.1	LIM1_Lmx1b	33..85	CDD:188757	27/51 (53%)
		LIM	92..146	CDD:295319	26/55 (47%)
		Homeobox	195..248	CDD:306543	43/52 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323174at33208
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	1	1.000	-	-		otm24731
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X1182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.950