DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and pdlim5

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_012817118.2	Gene:	pdlim5 / 548530	XenbaseID:	XB-GENE-854114	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	291	Identity:	66/291 - (22%)
Similarity:	110/291 - (37%)	Gaps:	79/291 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 TPVPINSCPT--PTGHSPLSSSSSNSNHNNNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVA 169
            :|:|.:|.||  ||..   |:....:.||::|                               |:
Frog   591 SPIPKSSFPTSKPTRK---STGGLYTGHNHSN-------------------------------VS 621

  Fly   170 APSPAGTSVATSQLGGAVAAAIAAAAAAAAAATTPTSTGPAATGSGNANGSGNGNGNGNGNGNGN 234
            ...|..|         |.::.|..::..:..::.|.::.|  ||......||....|
Frog   622 VEVPPAT---------ATSSKIMPSSYKSPPSSKPVTSKP--TGWQTVPSSGQVTNN-------- 667

  Fly   235 GNGNGGGAATASAAAASKLSA---------DCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNV 290
                   |:.|....|:..|.         ....|.|  ||.......:|..|.:.|...||:.:
Frog   668 -------ASNAVKPVANNKSVPPPWIEDQDTLVQRAE--HIPAGTRTPMCAICNKVIRGPFLLAL 723

  Fly   291 GDANWHEQCLACCYCGMQLHHTCYV-RNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNF 354
            | .:||.:...|.:|...:....:| ....|||::.|::||..:|:.|...||.:  |:..:..
Frog   724 G-KSWHPEEFNCAHCKSSMAEMGFVEEKGGLYCEICYEKLFAPECARCQRKILGE--VINALKQ- 784

  Fly   355 VFHLPCFVCYACRLPLQKGEQFMLRDGQLFC 385
            .:|:.||||.||:.|: :...|.|.||:.:|
Frog   785 TWHVSCFVCVACQTPI-RNSVFHLEDGEPYC 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	14/52 (27%)
		LIM	333..388	CDD:295319	18/53 (34%)
		Homeobox	427..480	CDD:278475
pdlim5	XP_012817118.2	PDZ	10..83	CDD:214570
		PRK14951	<80..216	CDD:237865
		DUF4749	212..320	CDD:406377
		LIM1_ENH	708..759	CDD:188837	14/51 (27%)
		LIM2_Enigma_like	767..818	CDD:188748	18/52 (35%)
		LIM3_ENH	826..880	CDD:188843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910