Protein Alignment Lmx1a and POU3F3

DIOPT Version :9

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_006227.1
• Gene: POU3F3 / 5455
• HGNCID: 9216
• Length: 500
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 95/464 - (20%)
• Similarity: 134/464 - (28%)
• Gaps: 204/464 - (43%)

  Fly   139 NNGGSSSNNLHSACNTL--TAAAVAAASAAAVAAPSP---------------------------- 173
            :|||...::.|.....|  .|||.|||:||||.|.||
Human    85 SNGGHMLSHAHQWVTALPHAAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDV 149

  Fly   174 ----------AGTSV---ATSQLG--------------GAVAAAIAAAAAAAAAATTPTSTGP-- 209
                      |||::   ....||              ||.|||.||||||||||..|:..|.
Human   150 KGGAGRDDLHAGTALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQ 214

  Fly   210 --------AATGSGNANG--------SGNGNGNGNG----------------------------- 229
                    :..|....||        .|.|.|.|.|
Human   215 PPPQSLLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAH 279

  Fly   230 ---------NGNGNGNGNGGGAATASAAAASKLSADCSGRTEVGHIKCEKNFELCEGCGQKIHDR 285
                     .|..:..|.||||.....:.......|.....::...  .|.|:     .::|...
Human   280 PHPPHPHHAQGPPHHGGGGGGAGPGLNSHDPHSDEDTPTSDDLEQF--AKQFK-----QRRIKLG 337

  Fly   286 FLM-NVGDA------NWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCHAILP 343
            |.. :||.|      |...|...|.:..:||       :.|..||
Human   338 FTQADVGLALGTLYGNVFSQTTICRFEALQL-------SFKNMCK-------------------- 375

  Fly   344 QELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCGFVG 408
                ::|:.|                                        .:|..|.:.......
Human   376 ----LKPLLN----------------------------------------KWLEEADSSTGSPTS 396

  Fly   409 LDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQ 473
            :|:    ....||:  ::.||.:....:...::.|.:.|||..:....||....|...||:|||.
Human   397 IDK----IAAQGRK--RKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVWFC 455

  Fly   474 NQRAKMKKI 482
            |:|.|.|::
Human   456 NRRQKEKRM 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	13/58 (22%)
		LIM	333..388	CDD:295319	2/54 (4%)
		Homeobox	427..480	CDD:278475	17/52 (33%)
POU3F3	NP_006227.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..63
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	122..190		6/67 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	231..319		14/87 (16%)
		POU	314..388	CDD:197673	19/151 (13%)
		Homeobox	409..463	CDD:395001	17/53 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..500		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030