DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmx1a and ct

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	147/723 - (20%)
Similarity:	226/723 - (31%)	Gaps:	259/723 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 QHQQHQQQQHQQQQQHP-----HQQHQQHQQQHAASTTPVPINSCPTPT---------GHSPLSS 125
            |.|||.|||||.||||.     ||||..|.||...|.:    ||.|...         ||..|..
  Fly   667 QQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQPNSGS----NSNPASNDHHHGHHLHGHGLLHP 727

  Fly   126 SS----------SNSNHN-----NNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVAAPSPAG 175
            ||          ||||.:     .|||.:|..||:.|.:|          .|..||::|:.....
  Fly   728 SSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANS----------TAQLAASLASTLNGT 782

  Fly   176 TSVATSQLGGAVAAAIAAAAAAAAAATTPTSTGPAATGSGNANGSGNGNGNGNGNGNGNGNGNGG 240
            .|:......|..|.|:||.|..|||.......|..|.....|..:..|:|.|:
  Fly   783 KSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVAAGGDGRGH------------ 835

  Fly   241 GAATASAAAASKL----SADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLA 301
                 ...|.|:|    .|..:||  :|.....|.    :....|:.:....|:.  .:..|.|.
  Fly   836 -----YRFADSELQLPPGASMAGR--LGESLIPKG----DPMEAKLQEMLRYNMD--KYANQALD 887

  Fly   302 CCYCGMQLHHTCYVRN--SKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIP---------NFV 355
            ..:...::.....|.|  .:|:.|.    :.|:...:.      .||:.:|.|         :..
  Fly   888 TLHISRRVRELLSVHNIGQRLFAKY----ILGLSQGTV------SELLSKPKPWDKLTEKGRDSY 942

  Fly   356 FHLPCFVCYACRLPLQK----------------------GEQFMLRD--GQLFCYRHDLEKEMFL 396
            ..:..:.|....:.|.|                      |:..|..|  ..:......|.|:..:
  Fly   943 RKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSV 1007

  Fly   397 AAAAAQ----HCGFVGLDEEDLLRPRDGRRGP----------------------KRPRTILTSQQ 435
            |....|    |.|......||...|......|                      :|.|.....::
  Fly  1008 AQHREQERRSHGGEDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQRER 1072

  Fly   436 RKQFKASFDQSPKPCRKVREALAKD-------------------TGL--------------SVRV 467
            .:|.:...|...|..|..:|.:|:.                   .|:              ::|.
  Fly  1073 EQQQRLRHDDQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRH 1137

  Fly   468 VQVWFQNQRAKMKKIQRKAKQ---------------------NGG---------------SGGGS 496
            |   |:.:.||:::.|::.:.                     ||.               :|..|
  Fly  1138 V---FEREIAKLQQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQRS 1199

  Fly   497 GSGRGTGNSSATDDKDTNDKEDKCV---KQELGGDSSGYLGGLDSTFASQPLNPNLP-------- 550
            ......|:||.:.|.:.:|.....:   |.|.||.            .:.|..|:.|
  Fly  1200 SLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGT------------PAPPAPPSGPGTGAGAPP 1252

  Fly   551 -FSPDDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNPHDML 614
             .:|....|:|| |...|.||                  |::...:.||.|.:.: :.::|...:
  Fly  1253 TAAPPTGGASSN-SAAPSPLS------------------NSILPPALSSQGEEFA-ATASPLQRM 1297

  Fly   615 ANLNNSLI 622
            |::.||||
  Fly  1298 ASITNSLI 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	8/53 (15%)
		LIM	333..388	CDD:295319	10/87 (11%)
		Homeobox	427..480	CDD:278475	13/85 (15%)
ct	NP_524764.1	CUT	886..955	CDD:280527	11/78 (14%)
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910