DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmx1a and zfh2

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_524623.2	Gene:	zfh2 / 43795	FlyBaseID:	FBgn0004607	Length:	3005	Species:	Drosophila melanogaster

Alignment Length:	681	Identity:	140/681 - (20%)
Similarity:	198/681 - (29%)	Gaps:	290/681 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PVGGSLYSLQQNHGGARFLDNPNPGSMTASSGNSLHLSNSNNNLPTSISGNNSPTATASLTGQHQ 77
            |..|.|.......|||.   .|...|..||.. :|..:.||:|....|        |..|..|.|
  Fly   368 PCSGFLQMQHMTTGGAY---TPQVSSFHASLA-ALAANESNDNRVKLI--------TEFLQQQLQ 420

  Fly    78 QHQQQ-------QH----------------QQQQQHPHQQHQQHQQQHAASTTPVPINSCPTPTG 119
            |||..       .|                ||:.:.|...|.|..|    |...:.|.|.|..|.
  Fly   421 QHQSSLFPSPCPDHPDLNGVDCKTCELLDIQQRSKSPSSSHHQFSQ----SLPQLQIQSQPQQTP 481

  Fly   120 H-SPLSSSSSNSNHNNNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVAAP-SPAGTSVATSQ 182
            | ||.|:|                                         ||.| ||:.:||
  Fly   482 HRSPCSNS-----------------------------------------VALPVSPSASSV---- 501

  Fly   183 LGGAVAAAIAAAAAAAAAATTPTSTGPAATGSGNANGSGNGNGNGNGNGNGNGNGNGGGAATASA 247
                         |:...|:|.||:......|.:.||...|
  Fly   502 -------------ASVGNASTATSSFTIGACSEHINGRPQG------------------------ 529

  Fly   248 AAASKLSADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHT 312
                   .||:        :||                .|:|....|          .|:|:.
  Fly   530 -------VDCA--------RCE----------------MLLNSARLN----------SGVQMS-- 551

  Fly   313 CYVRNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFM 377
              .|||   ||.       :||..|               |:.:.      |...|.:...|:.
  Fly   552 --TRNS---CKT-------LKCPQC---------------NWHYK------YQETLEIHMREKH- 582

  Fly   378 LRDGQLFC-YRHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKA 441
             .||:..| |....::...||...:..||:                .|.|......|...|...:
  Fly   583 -PDGESACGYCLAGQQHPRLARGESYSCGY----------------KPYRCEICNYSTTTKGNLS 630

  Fly   442 SFDQSPKPCRKVRE-----------ALAKDTG---LSVRVVQVWFQNQRAKMKKIQRKAKQNGGS 492
            ...||.|....::|           |.|..||   ||            :...::......|.||
  Fly   631 IHMQSDKHLNNMQELNSSQNMVAAAAAAAVTGKLLLS------------SSSPQVTAACPSNSGS 683

  Fly   493 GGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYP 557
            |.||||....|.:::                 |.|:::..:.|.:|:.|:...|.|      :..
  Fly   684 GAGSGSSNIVGGTAS-----------------LSGNATPSVTGANSSNANAGSNTN------NAG 725

  Fly   558 ANSNDSF----CSSDLSLDGS------------NFDQLDDDADSL-SLNNLELQSTSSSGNQHSH 605
            .....||    ||.|.|:..:            |...|.::...: :.|.|:.|..|.:||..||
  Fly   726 TKPKPSFRCDICSYDTSVARNLRIHMTSEKHTHNMAVLQNNIKHIQAFNFLQQQQQSGTGNIASH 790

  Fly   606 SHSN--PHDMLANL--NNSLINPIDKLYLMQ 632
            |..:  |...||:|  |.:|:  |..|:..|
  Fly   791 SSGSFMPEVALADLAYNQALM--IQLLHQQQ 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	10/51 (20%)
		LIM	333..388	CDD:295319	11/55 (20%)
		Homeobox	427..480	CDD:278475	12/66 (18%)
zfh2	NP_524623.2	C2H2 Zn finger	561..581	CDD:275368	5/40 (13%)
		C2H2 Zn finger	616..633	CDD:275368	2/16 (13%)
		C2H2 Zn finger	1515..1542	CDD:275371
		C2H2 Zn finger	1543..1564	CDD:275371
		HOX	1797..1853	CDD:197696
		Homeobox	2158..2210	CDD:278475
		Homeobox	2764..2816	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444983
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840