DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmx1a and zfh1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_733401.3	Gene:	zfh1 / 43650	FlyBaseID:	FBgn0004606	Length:	1206	Species:	Drosophila melanogaster

Alignment Length:	888	Identity:	158/888 - (17%)
Similarity:	248/888 - (27%)	Gaps:	373/888 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QQNHGGA--RFLDNPNPGSMTASSGNSLHLSNSNNNLPTSISGNN------------------SP 66
            |.|..|:  |:..:|      .:|.|:...:|:|||..:|.|.||                  ||
  Fly   117 QSNMSGSSRRYAKSP------LASNNNSSTANANNNSTSSQSMNNNSELAKNHNSANKMSPMCSP 175

  Fly    67 ----------------------------TATASLTGQ--------HQQHQQQQHQQQQQHPHQQH 95
                                        .|.|||..|        .||.|||..||||....|||
  Fly   176 GSLTPGDLFAQLQHPPPQLPPHLHAQFMAAAASLAMQSARTASSPSQQQQQQLQQQQQLQQQQQH 240

  Fly    96 QQHQQQHAASTTPVPINSCPTPTGHS-PLSSSSSNSNHNNNNNNNNGG----------------S 143
            |...||......|...:|..:.:.:. .||:..|.|:..:...:.:|.                .
  Fly   241 QMAMQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTASFASREQLE 305

  Fly   144 SSNNLHSACNTLTAAAVAAASAAA----------------------------------------- 167
            ....|||.|.   .|||:..|...
  Fly   306 QHEQLHSPCG---PAAVSNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFK 367

  Fly   168 ---------VAAPSPAGTSVATSQL--GGAVAAAIAA-------------AAAAAAAATTPTSTG 208
                     .:...|.|......:.  .|:.::.:.:             .|.......:|.|..
  Fly   368 HHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGSAS 432

  Fly   209 PAATGSGNANGSGN--------GNGNGNGNGNGNGNGNGGGAATA-------------------- 245
            .|:..|.:.:|.|.        |..:.......:....||.||.|
  Fly   433 SASRRSPSDHGKGKLPEQPSLPGLPHPMSYFASDAQVQGGSAAPAPFPPFHPNYMNAALLAFPHN 497

  Fly   246 -SAAAAS--------------KLSADCSGRTEVGHIKCEKNFELCEGCGQKIHD--------RFL 287
             .||||.              :|||       .|..:.|:..|  |...|:.||        :.:
  Fly   498 FMAAAAGLDPRVHPYSIQRLLQLSA-------AGQQQREEERE--EQQKQQQHDEEETPDEPKLV 553

  Fly   288 MNVGDANWHEQC----------------------------------------------------- 299
            |::.:....|..
  Fly   554 MDIEEPETKEMAPTPEATEAATPIKREESREASPDPESYRSSSQAIKQEQEPLNVAEERQTPVEE 618

  Fly   300 ---------LACCYCGMQLHH-TCYVRNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNF 354
                     |.|..|..|.:| |..|::.|:.|                 .::.:||
  Fly   619 HAPVEHAADLRCSRCSKQFNHPTELVQHEKVLC-----------------GLIKEEL-------- 658

  Fly   355 VFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPRD 419
                              .:.|..:....|.          ||:|:.:......:|.|:..|...
  Fly   659 ------------------EQHFQQQQATSFA----------LASASEEDEEDEEMDVEEEPRQES 695

  Fly   420 GRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQR 484
            |.| ..|.||.:..:|::|.|..:..:.:|.|.....:|....|..|||||||||.|::.:|:|
  Fly   696 GER-KVRVRTAINEEQQQQLKQHYSLNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQ- 758

  Fly   485 KAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNL 549
             :.||..:.|.:       .....|.:.:..:||:               .||.:....||.|..
  Fly   759 -SFQNNQAAGAA-------PPMPIDSQASLTREDQ---------------PLDLSVKRDPLTPKS 800

  Fly   550 PFSPDDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLN----------------NLELQSTSS 598
            ..||......|.::.....::|.............|:|.:                |.:|.||..
  Fly   801 ESSPPYIAPPSGEALNPEAINLSRKFSTSASMSPASISPSSAAALYFGAAPPPSPPNSQLDSTPR 865

  Fly   599 SGNQHSHSHSNPHDMLANLNNSLINPIDKLYLMQ-NSYFSSEH 640
            ||  .:.....|:.:..:|      |::.|:.|: ...|:|.|
  Fly   866 SG--QAFPGLPPYMLPMSL------PMEALFKMRPGGDFASNH 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	15/122 (12%)
		LIM	333..388	CDD:295319	4/54 (7%)
		Homeobox	427..480	CDD:278475	19/52 (37%)
zfh1	NP_733401.3	C2H2 Zn finger	291..311	CDD:275368	0/19 (0%)
		C2H2 Zn finger	326..346	CDD:275368	0/19 (0%)
		zf-C2H2	355..377	CDD:278523	0/21 (0%)
		C2H2 Zn finger	357..377	CDD:275368	0/19 (0%)
		zf-H2C2_2	369..391	CDD:290200	2/21 (10%)
		Homeobox	703..755	CDD:278475	19/51 (37%)
		C2H2 Zn finger	969..989	CDD:275368
		zf-H2C2_2	981..1006	CDD:290200
		COG5048	992..>1045	CDD:227381
		C2H2 Zn finger	997..1017	CDD:275368
		zf-H2C2_2	1009..1034	CDD:290200
		C2H2 Zn finger	1025..1042	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910