DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and lab

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_476613.1	Gene:	lab / 40817	FlyBaseID:	FBgn0002522	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	300	Identity:	77/300 - (25%)
Similarity:	104/300 - (34%)	Gaps:	96/300 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QQNHGGARFLDNPNPGSMTASSGNSL---HLSNSNNNLPTSISGNNSPTATASLTGQHQQHQQQQ 83
            ||:..|:..||..:...|.|...:.|   ||.|..||                   .||  ||.|
  Fly   268 QQHLAGSYALDAMDSLGMHAHMHHGLPHGHLGNLANN-------------------PHQ--QQPQ 311

  Fly    84 HQQQQQHPHQQHQQHQQQHAASTTPVPINSCPTPTGHSPLSSSSSNSNHNNNNNNNNG----GSS 144
            .|||||.||||.|..|.|              :|..|.....:|.:.|...|.....|    |||
  Fly   312 VQQQQQQPHQQPQHPQNQ--------------SPAAHQQHHQNSVSPNGGMNRQQRGGVISPGSS 362

  Fly   145 SNNLHSACNTLTAAAVAAASAAAVAAPSPAGTS-------------VATSQLGGAVAAAIAAAAA 196
            :::..||.|        .|..|:..:.||..:|             |...|.....|:.||:...
  Fly   363 TSSSTSASN--------GAHPASTQSKSPNHSSSIPTYKWMQLKRNVPKPQAPKLPASGIASMHD 419

  Fly   197 AAAAATTPTSTGPAATGSGNANG----SGNGN----------------------GNGNGNGNGNG 235
            ...........|....|||..||    .|||:                      |:.:.||.|.|
  Fly   420 YQMNGQLDMCRGGGGGGSGVGNGPVGVGGNGSPGIGGVLSVQNSLIMANSAAAAGSAHPNGMGVG 484

  Fly   236 NGNGGGAATASAAAASKLSADCSGRTEVGH---IKCEKNF 272
            .|:|.|.::.|.::    :.:.||||...:   .:.||.|
  Fly   485 LGSGSGLSSCSLSS----NTNNSGRTNFTNKQLTELEKEF 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475
lab	NP_476613.1	Homeobox	505..557	CDD:278475	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I3555
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.000