DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and LMX1B

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001167617.1	Gene:	LMX1B / 4010	HGNCID:	6654	Length:	406	Species:	Homo sapiens

Alignment Length:	398	Identity:	156/398 - (39%)
Similarity:	207/398 - (52%)	Gaps:	79/398 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 LCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCC 338
            :||||.:.|.|||||.|.:::|||:||.|..|...|..:||.|:.|||||.||.:||..|||.|.
Human    55 VCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCM 119

  Fly   339 HAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEM-FLAAAAAQ 402
            ..|.|.|.|||.: ..|:||.||.|..|...|:||::|:|::|||.| :.|.|||. .|::.:..
Human   120 EKIAPTEFVMRAL-ECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLC-KGDYEKEKDLLSSVSPD 182

  Fly   403 HCGFVGLDEED-LLRPRDGR--------------RGPKRPRTILTSQQRKQFKASFDQSPKPCRK 452
            ....|..::|| .::|..|:              |.|||||||||:|||:.|||||:.|.|||||
Human   183 ESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRK 247

  Fly   453 VREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQ-----------NGGSGGGSG------SGR 500
            |||.||.:|||||||||||||||||||||:.|:.:|           .|..|.|.|      |.|
Human   248 VRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQGEPGPGQGLGQEVLSSR 312

  Fly   501 GTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYPANSNDSFC 565
            ..|..::........::...::|...|.|..:..||..        |.:|         .|||.
Human   313 MEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQQGLTP--------PQMP---------GNDSI- 359

  Fly   566 SSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNPHDMLANLNNSLINPIDKLYL 630
                      |..:|.|....||::..|.|:.                :.:|...:.||||:||.
Human   360 ----------FHDIDSDTSLTSLSDCFLGSSD----------------VGSLQARVGNPIDRLYS 398

  Fly   631 MQNSYFSS 638
            ||:|||:|
Human   399 MQSSYFAS 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	28/51 (55%)
		LIM	333..388	CDD:295319	26/54 (48%)
		Homeobox	427..480	CDD:278475	43/52 (83%)
LMX1B	NP_001167617.1	LIM1_Lmx1b	56..108	CDD:188757	28/51 (55%)
		LIM2_Lmx1a_Lmx1b	115..169	CDD:188764	25/55 (45%)
		Homeobox	222..275	CDD:278475	43/52 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9172
eggNOG	1	0.900	-	-		E33208_3BAC6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3205
Isobase	1	0.950	-	0	Normalized mean entropy	S3240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323174at33208
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	1	1.000	-	-		otm41868
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X1182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810