DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and ABLIM1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006717900.1	Gene:	ABLIM1 / 3983	HGNCID:	78	Length:	788	Species:	Homo sapiens

Alignment Length:	399	Identity:	83/399 - (20%)
Similarity:	125/399 - (31%)	Gaps:	127/399 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCH 339
            |.|||:.|.:...:...|..||..|..|..||..|......::...||:.||..||||||.: ||
Human   166 CAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEA-CH 229

  Fly   340 AILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQH- 403
            ..:..:::.....:  :|..|..|..|.....:||                  ||:|..:...|
Human   230 QFITGKVLEAGDKH--YHPSCARCSRCNQMFTEGE------------------EMYLQGSTVWHP 274

  Fly   404 -CGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRV 467
             |......||.|..|...|.                 .:.|..|        ::|.:.||.|..:
Human   275 DCKQSTKTEEKLRLPNIRRS-----------------SSDFFYS--------KSLIRRTGRSPSL 314

  Fly   468 VQVWFQNQRAKMKKI-QRKAKQNGGSGGGSGSGRGTGNSSATDDKD------------------- 512
                 |..|...:.| .|......||.|.:...:  .::...|.||
Human   315 -----QPTRTSSESIYSRPGSSIPGSPGHTIYAK--VDNEILDYKDLAAIPKVKAIYDIERPDLI 372

  Fly   513 ------TNDKEDKCVKQELG---------GDSSGY-------------LGGLDSTFASQPLNPNL 549
                  |:..:||..:|.||         ..:.||             .|.::|     |:....
Human   373 TYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINS-----PVYSRH 432

  Fly   550 PFSPDDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNP---H 611
            .::|.  .:.|...|...:|...|              :..|....|||....||.|..||   |
Human   433 SYTPT--TSRSPQHFHRPELLSPG--------------VQRLSYLRTSSLSPTHSDSRPNPPFRH 481

  Fly   612 DMLANLNNS 620
            ..:.::..:
Human   482 HFIPHIKGN 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	16/51 (31%)
		LIM	333..388	CDD:295319	10/54 (19%)
		Homeobox	427..480	CDD:278475	8/52 (15%)
ABLIM1	XP_006717900.1	LIM1_abLIM	39..90	CDD:188713
		LIM2_abLIM	95..150	CDD:188714
		LIM3_abLIM	166..217	CDD:188715	15/50 (30%)
		LIM4_abLIM	225..280	CDD:188716	14/75 (19%)
		AbLIM_anchor	318..752	CDD:292800	35/196 (18%)
		VHP	753..788	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910