Protein Alignment Lmx1a and CG4328

DIOPT Version :9

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_648567.2
• Gene: CG4328 / 39405
• FlyBaseID: FBgn0036274
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 675
• Identity: 212/675 - (31%)
• Similarity: 295/675 - (43%)
• Gaps: 188/675 - (27%)

  Fly     3 EFYPMPTNLNPVGGSLYSLQQNHGGARFLDNPNPGSMTASSGNSLHLSNSNNNLPTSISGNNSPT 67
            |.:||...:.|:.   ...||...||..|  |..|.:     |.|.|.|.|..:.|      :||
  Fly     4 EHHPMQIGMFPMD---IKCQQQQLGAGQL--PQTGGL-----NQLLLLNGNERMLT------TPT 52

  Fly    68 ATASLTGQHQQHQQQQHQQQQQHPHQQHQQHQQQHAASTTPVPINSCPTPTG---HSPLSSSSSN 129
            ..|:                                 |.......|..|..|   :..::|.|..
  Fly    53 TAAT---------------------------------SVVVAAGRSASTKAGVAHNDKMASVSRT 84

  Fly   130 SNHNNNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAA 194
            .|.:.:|:|::..|||::.:|:.|
  Fly    85 VNGSCSNHNSSNSSSSSSTNSSSN----------------------------------------- 108

  Fly   195 AAAAAAATTPTSTGPAATGSGNANGSGNGNGNGNGN---------GNGNGNGNGGGAATASAAAA 250
               .|....|...||   |:|...|:|.|:|.|..|         |..:.||..|.|..|:..:|
  Fly   109 ---MAINKQPMGMGP---GTGTGMGTGTGHGPGPPNHTHCNRITLGECSLNGMDGFATPAAPPSA 167

  Fly   251 SK-------LSADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQ 308
            |.       ::::.....|:|..........|..|.|.|.||::|.|.:.::||.||.|..|.:.
  Fly   168 SNTPQAPLGMASNSGMGMELGLAMASPQLSQCAHCCQPICDRYIMRVVENSFHEGCLKCTACSLH 232

  Fly   309 LHHTCYVRNSKLYCKMDYDRLFGVK--CSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQ 371
            |.|:||.|..||||::||:||: ::  |..|...|...|||||...| ||||.||.|..|...|:
  Fly   233 LVHSCYAREGKLYCRVDYERLY-IRNHCLGCGLKIAADELVMRCHEN-VFHLKCFACVVCGALLK 295

  Fly   372 KGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPR-DGRRGPKRPRTILTSQQ 435
            ||||::::.||||| |.|.|||:.:    .|...|.|   ::|..|: |||||||||||||.:||
  Fly   296 KGEQYVVKQGQLFC-RFDYEKEVEM----LQGYDFYG---DELFPPKLDGRRGPKRPRTILNTQQ 352

  Fly   436 RKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGR 500
            |:.|||||:.||||||||||.||||||||:|:|||||||||||:||||:||||...|.|
  Fly   353 RRAFKASFEVSPKPCRKVRENLAKDTGLSLRIVQVWFQNQRAKVKKIQKKAKQEPPSKG------ 411

  Fly   501 GTGNSSATDDKDTNDKEDKC----VKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYPANSN 561
                  |:|.:|:.:..|..    :|.|...||...|              ..|:|      .::
  Fly   412 ------ASDSQDSQESLDSSLATKIKDEAHSDSESQL--------------ESPYS------TTS 450

  Fly   562 DSF----CSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQH-------SHSHSNPHDMLA 615
            |..    |:            :.|:.:.:..|.:|....:.:.|..       ..|::....::.
  Fly   451 DGLTRMRCT------------IKDEQEQVPFNCMETNKENCNKNSEPILNTILGLSYATFQQLMG 503

  Fly   616 NL-NNSLINPIDKLYLMQNSYFSSE 639
            .. ...:|||||:||.||:|||..|
  Fly   504 PFAQTPMINPIDRLYSMQSSYFRPE 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	24/51 (47%)
		LIM	333..388	CDD:295319	27/56 (48%)
		Homeobox	427..480	CDD:278475	43/52 (83%)
CG4328	NP_648567.2	LIM1_Lmx1b	199..251	CDD:188757	24/51 (47%)
		LIM	259..313	CDD:295319	28/55 (51%)
		COG5576	<332..439	CDD:227863	69/118 (58%)
		HOX	341..393	CDD:197696	42/51 (82%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	0.796	Domainoid score	I4515
eggNOG	1	0.900	-	-		E33208_3BAC6
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	253	1.000	Inparanoid score	I3205
Isobase	1	0.950	-	0	Normalized mean entropy	S3240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143053at6656
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	1	1.000	-	-		otm14531
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	P	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X1182
	12	11.850