DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and prrx1b

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_017207930.1	Gene:	prrx1b / 337089	ZFINID:	ZDB-GENE-030131-9033	Length:	267	Species:	Danio rerio

Alignment Length:	225	Identity:	52/225 - (23%)
Similarity:	78/225 - (34%)	Gaps:	76/225 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 DEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQN 474
            :.|.|......:|..:|.||...|.|.:..:..|:::..|...|||.||:...|:...|||||||
Zfish    82 ENEQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQN 146

  Fly   475 QRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDST 539
            :|||.::.:|....:                          |....:|...|          |.|
Zfish   147 RRAKFRRNERAMLAS--------------------------KNASLLKSYSG----------DVT 175

  Fly   540 FASQPLNPNLPFSPDDY---------------------------PANSN-----DSFCSSDLSLD 572
            ...||:.|.....|:||                           |..||     ...|::..|..
Zfish   176 AVEQPIVPRPAPRPNDYLSWGSAAPYSWYPRPEGGPMRVPQKMLPTESNTMATYPPTCANTTSTQ 240

  Fly   573 GSNFDQLDDDADSLSLNNLELQSTSSSGNQ 602
            |.|.      |:|::  ||.|::...:.||
Zfish   241 GMNM------ANSIA--NLRLKAKEYNLNQ 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	22/52 (42%)
prrx1b	XP_017207930.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910