DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and AgaP_AGAP005137

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_558527.3	Gene:	AgaP_AGAP005137 / 3289904	VectorBaseID:	AGAP005137	Length:	432	Species:	Anopheles gambiae

Alignment Length:	450	Identity:	228/450 - (50%)
Similarity:	278/450 - (61%)	Gaps:	88/450 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 LSADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVG-DANWHEQCLACCYCGMQLHHTCYVR 316
            ||:|.     ||.||.||..|:||||||||.||:.|.:. |..||||||.||.|.:||..|||.:
Mosquito     2 LSSDI-----VGTIKSEKTQEICEGCGQKIKDRYFMKLSPDQFWHEQCLLCCICRIQLSQTCYTK 61

  Fly   317 NSKLYCKMDYDRLFGVK-------------------------CSSCCHAILPQELVMRPIPNFVF 356
            |:|:|||.||.|:|||.                         |..|...|.|.|:||| ..:.|:
Mosquito    62 NTKVYCKDDYYRIFGVSSVHQQNQQHHQQHGQQQQQQQHQRDCYGCGERIAPIEMVMR-AKHLVY 125

  Fly   357 HLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAA-------------QHCGFVG 408
            ||.||:||.|..||||||.|.:|.|:|.| :|||||:.:.:||||             .|.|..|
Mosquito   126 HLHCFLCYTCNRPLQKGEPFSIRAGKLIC-QHDLEKDFYGSAAAAAAAAAAAAAAAMHHHHGGAG 189

  Fly   409 L----------------DE---EDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVR 454
            .                |:   :|.||.||||||||||||||||.||:|||||||.|||||||||
Mosquito   190 AGLGPHLPPAAHLYGDGDDYLLDDGLRTRDGRRGPKRPRTILTSAQRRQFKASFDVSPKPCRKVR 254

  Fly   455 EALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATD-DKDTNDKED 518
            ||||||||||||||||||||||||||||.||:|.|.              :.||| :|:.:||||
Mosquito   255 EALAKDTGLSVRVVQVWFQNQRAKMKKILRKSKANA--------------NGATDGEKNHSDKED 305

  Fly   519 KCVKQEL-GGDSSGYLGGLDSTF--ASQPLNPNLPFSPDDYPANSNDSFCSSDLSLDGSNFDQLD 580
            |.:|.|. ..|.|.|| ||||::  :|||||||||:|| |:|.||:.|.||||:|||.| ||.:|
Mosquito   306 KSIKLESPSSDHSHYL-GLDSSYSSSSQPLNPNLPYSP-DFPDNSDASLCSSDISLDES-FDNVD 367

  Fly   581 D-DADSLSLNNLELQ-STSSSGNQHSHSHSNPHDMLANLNNSLINPIDKLYLMQNSYFSS 638
            : .:|::||.||:|| :..|:|...:|:::....|:|:.....|..||||||||||||:|
Mosquito   368 EATSDTMSLQNLDLQPNLHSNGQLVNHNNNTIGSMMASNMAGSITHIDKLYLMQNSYFNS 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	32/52 (62%)
		LIM	333..388	CDD:295319	27/79 (34%)
		Homeobox	427..480	CDD:278475	49/52 (94%)
AgaP_AGAP005137	XP_558527.3	LIM	19..71	CDD:295319	31/51 (61%)
		LIM	102..157	CDD:295319	27/56 (48%)
		Homeobox	227..280	CDD:278475	49/52 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	111	1.000	Domainoid score	I12242
eggNOG	1	0.900	-	-		E33208_3BAC6
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136689
Inparanoid	1	1.050	361	1.000	Inparanoid score	I4391
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323174at33208
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	1	1.000	-	-		oto110186
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1182
TreeFam	1	0.960	-	-
	12	11.930