DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and HOXD3

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	268	Identity:	71/268 - (26%)
Similarity:	98/268 - (36%)	Gaps:	83/268 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 CGFVGLDEEDLLRPRDGRRGP--KRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVR 466
            |...|...||...|     ||  ||.||..||.|..:.:..|..:...||..|..:|....|:.|
Human   177 CATAGESCEDKSPP-----GPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTER 236

  Fly   467 VVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSS- 530
            .:::||||:|.|.||.| |||             |..:|.|:...:.:        ..|||.:.
Human   237 QIKIWFQNRRMKYKKDQ-KAK-------------GILHSPASQSPERS--------PPLGGAAGH 279

  Fly   531 -GYLGGL------------DSTFA------------SQPLNPNLP---------FSPDDYPANSN 561
             .|.|.|            ...||            :.||:..||         |.|  :|..||
Human   280 VAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEP--HPMASN 342

  Fly   562 -DSFCSSDLS----LDGSNFDQLDDDADS--LSLNNLELQSTSS---------SGNQHSHSHSNP 610
             ..|.|::|.    ..|.||.:....|..  .:|.:|...|::|         .||.| |...:|
Human   343 GGGFASANLQGSPVYVGGNFVESMAPASGPVFNLGHLSHPSSASVDYSCAAQIPGNHH-HGPCDP 406

  Fly   611 HDMLANLN 618
            |....:|:
Human   407 HPTYTDLS 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	18/52 (35%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		8/24 (33%)
		Antp-type hexapeptide	160..165
		Homeobox	198..250	CDD:306543	18/51 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		10/48 (21%)
		DUF4074	369..430	CDD:315871	12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910