DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Zfhx4

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006232224.1	Gene:	Zfhx4 / 310250	RGDID:	1563022	Length:	3619	Species:	Rattus norvegicus

Alignment Length:	251	Identity:	61/251 - (24%)
Similarity:	94/251 - (37%)	Gaps:	60/251 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 DEED--LLRPRDGRRG-----PKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRV 467
            |:||  ......|..|     .||.||.:|.:|.:.....:.....|.||:.:.:|::.||..||
  Rat  2586 DKEDNNCSEKEGGNSGEDQHRDKRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRV 2650

  Fly   468 VQVWFQNQRAKMKKIQRKAKQNGGS--------------------------GGGSGSGRGTGNSS 506
            |||||||.||:.:|.|.:|.....|                          ..|..:|.....|.
  Rat  2651 VQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNEGKQAGYSLPPSP 2715

  Fly   507 ATDDKDTNDKEDKCV----------KQELGGDSSGYLGGLDSTFASQ--PLNPNLPFSPDDYPAN 559
            ....:|..:...|.:          |.:|..::.  |....||..|:  .|:|....||..:.|.
  Rat  2716 LISTEDGGESPQKYIYFDYPSLPLTKIDLSSENE--LASTVSTPVSKTAELSPKNLLSPSSFKAE 2778

  Fly   560 SNDSFCSSDL------SLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSN 609
                 |..|:      |.| :.:||...|.|..|..|..: |.:::|::.:....|
  Rat  2779 -----CPEDVENLNAPSAD-AGYDQNKTDFDETSSINTAI-SDATTGDEGAADMEN 2827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	21/52 (40%)
Zfhx4	XP_006232224.1	C2H2 Zn finger	620..641	CDD:275368
		C2H2 Zn finger	651..672	CDD:275368
		C2H2 Zn finger	706..723	CDD:275368
		C2H2 Zn finger	1404..1424	CDD:275371
		C2H2 Zn finger	1432..1449	CDD:275371
		SFP1	<1489..1616	CDD:227516
		C2H2 Zn finger	1548..1572	CDD:275368
		C2H2 Zn finger	1600..1618	CDD:275368
		COG5576	2106..2245	CDD:227863
		HOX	2135..2190	CDD:197696
		Homeobox	2234..2288	CDD:395001
		PspC_subgroup_1	<2398..>2476	CDD:411407
		COG5576	2544..>2666	CDD:227863	29/79 (37%)
		Homeobox	2611..2664	CDD:395001	21/52 (40%)
		Homeobox	2934..2987	CDD:395001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910