DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmx1a and lhx5

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571293.1	Gene:	lhx5 / 30465	ZFINID:	ZDB-GENE-980526-484	Length:	399	Species:	Danio rerio

Alignment Length:	408	Identity:	122/408 - (29%)
Similarity:	175/408 - (42%)	Gaps:	83/408 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCH 339
            |.||.:.|.||||:||.|..||.:|:.||.|...|...|:.|:.|||||:|:.|.||.||:.|..
Zfish     5 CAGCERPILDRFLLNVLDRAWHAKCVQCCECNCNLTEKCFSRDGKLYCKIDFFRRFGTKCAGCLQ 69

  Fly   340 AILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQ-FMLRDGQLFCYRHDLEKEMFLAAAAAQH 403
            .|.|.:||.| ..:.||||.||.|..|...|..||: :::.:.:..|      ||.:|:|:|.:.
Zfish    70 GISPSDLVRR-ARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVC------KEDYLSASAIKE 127

  Fly   404 CGFVGLDE--------------EDLLRPRDG---------------------RRGPKRPRTILTS 433
            .....:..              :|..:..|.                     |||   |||.:.:
Zfish   128 VNLNSVSSCTDRSLSPDLPDQIQDDTKETDNSTSSDKDTNNNENEEQNSCTKRRG---PRTTIKA 189

  Fly   434 QQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGG--- 495
            :|.:..||:|..:|||.|.:||.||::|||::||:||||||:|:|    :|:.||....|..
Zfish   190 KQLETLKAAFVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSK----ERRMKQLSALGARRHA 250

  Fly   496 --SGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNL-----PFSP 553
              .|..|........:|.|.           :|.....|.|.....:....:|.:.     |.|.
Zfish   251 FFRGPRRMRPLGGRLEDPDI-----------MGPGGYSYYGEYQGDYYGPVVNYDFFPHGPPSSQ 304

  Fly   554 DDYPANSNDSFCSSDLSLDG---SNFDQLDDD--ADSLSLNNLELQSTSSSGNQHSHSH------ 607
            ...||.|.....|...:|:|   |.....||.  .|.:|..:........:|..||:..
Zfish   305 AHSPAESPYLLSSGSGALEGGPVSAHHPSDDQRFTDMISHADTPSPEPGMTGPLHSNPQGEGGFT 369

  Fly   608 SNPHDMLANLNNSLINPI 625
            .:|...||| |.|...|:
Zfish   370 GSPPFPLAN-NTSYSGPM 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	26/51 (51%)
		LIM	333..388	CDD:295319	20/55 (36%)
		Homeobox	427..480	CDD:278475	28/52 (54%)
lhx5	NP_571293.1	LIM1_Lhx1_Lhx5	5..56	CDD:188753	25/50 (50%)
		LIM2_Lhx1_Lhx5	64..119	CDD:188761	21/61 (34%)
		COG5576	126..>242	CDD:227863	36/122 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..185		6/51 (12%)
		Homeobox	183..236	CDD:278475	28/56 (50%)
		GATA-N	298..>390	CDD:283099	23/90 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..399		23/87 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910