DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and lhx3

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571283.1	Gene:	lhx3 / 30455	ZFINID:	ZDB-GENE-980526-131	Length:	398	Species:	Danio rerio

Alignment Length:	324	Identity:	111/324 - (34%)
Similarity:	159/324 - (49%)	Gaps:	47/324 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 ADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSK 319
            :.|............::..:|.||.|.|.|||::.|.|.:||.:||.|..|..||...|:.|...
Zfish     8 SSCQNAGNYTRYSSSQDIPVCAGCNQHIVDRFILKVLDRHWHSKCLKCSDCQSQLADKCFSRGDS 72

  Fly   320 LYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKG-EQFMLRDGQL 383
            :|||.|:.:.||.||::|...|.|.::|.| ..:||:||.||.|..|:..|..| |.:::.|.:|
Zfish    73 VYCKDDFFKRFGTKCAACQQGIPPTQVVRR-AQDFVYHLHCFACIVCKRQLATGDEYYLMEDSRL 136

  Fly   384 FCYRHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPK 448
            .| :.|.|                      ..:.|:.....|||||.:|::|.:..|.:::.|||
Zfish   137 VC-KADYE----------------------TAKQREADSTAKRPRTTITAKQLETLKNAYNNSPK 178

  Fly   449 PCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKA-KQNGGS-GGGSGSGRGTGNSSATDDK 511
            |.|.|||.|:.:|||.:|||||||||:|||.|::::.| :|..|. .......|||..|    ||
Zfish   179 PARHVREQLSTETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGTSKS----DK 239

  Fly   512 DTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYPANSNDSFCSSDLSLDGSN 575
            |:.        ||.|.||..     :.:|..:|...:|..|...|   |:.|..|..||..|.|
Zfish   240 DST--------QEDGMDSDA-----EVSFTDEPPMSDLGHSNGIY---SSLSESSPALSRQGGN 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	24/51 (47%)
		LIM	333..388	CDD:295319	21/55 (38%)
		Homeobox	427..480	CDD:278475	30/52 (58%)
lhx3	NP_571283.1	LIM1_Lhx3b	25..79	CDD:188851	23/53 (43%)
		LIM2_Lhx3_Lhx4	87..142	CDD:188762	20/56 (36%)
		Homeobox	157..210	CDD:278475	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..294		29/100 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910