DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and pou3f3b

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_958855.2	Gene:	pou3f3b / 30321	ZFINID:	ZDB-GENE-980526-140	Length:	443	Species:	Danio rerio

Alignment Length:	154	Identity:	39/154 - (25%)
Similarity:	49/154 - (31%)	Gaps:	55/154 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PTNLNPVGGSLYSLQQNHGGARFLDNPNPGSMTASSGNSLHLSNSNNNLP------TSISGNNSP 66
            |.:.:|||.:....||:      :.| |.|.....||.:||     :..|      |......|.
Zfish   101 PWSSSPVGMTGSPQQQD------VKN-NSGRDDLHSGTALH-----HRAPHLGPHQTHAGAWGST 153

  Fly    67 TAT--ASLTGQHQQHQ-----------------------------------QQQHQQQQQHPHQQ 94
            ||.  .||||..||.|                                   :..|.....|.|.|
Zfish   154 TAAHIPSLTGSQQQQQSLIYSQPGGFTVNGMLSPPGSQSLVHPGLVRGDTPELDHSSHHHHHHHQ 218

  Fly    95 HQQHQQQHAASTTPVPINSCPTPT 118
            ||.|||.|....:..|.:...|||
Zfish   219 HQHHQQAHHGVNSHDPHSDEDTPT 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475
pou3f3b	NP_958855.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..150		15/60 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..244		14/61 (23%)
		POU	238..312	CDD:197673	3/5 (60%)
		Homeobox	333..386	CDD:278475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030