DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Pax6

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006234695.1	Gene:	Pax6 / 25509	RGDID:	3258	Length:	436	Species:	Rattus norvegicus

Alignment Length:	226	Identity:	50/226 - (22%)
Similarity:	88/226 - (38%)	Gaps:	29/226 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 GLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWF 472
            |.|.::.......:|..:|.||..|.:|.:..:..|:::..|....||.||....|....:||||
  Rat   208 GEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWF 272

  Fly   473 QNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLG-GL 536
            .|:|||.:: :.|.:........:.|.....:|.:|.......:....|.....|...|... .|
  Rat   273 SNRRAKWRR-EEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTAL 336

  Fly   537 DSTFASQPLNP------NLPFSPDDYPANSNDSFC--SSDLSLDGSNFDQLDDDADSLSLNNLEL 593
            .:|:::.|..|      |||..| ..|:.::...|  .:..|::|.::|
  Rat   337 TNTYSALPPMPSFTMANNLPMQP-PVPSQTSSYSCMLPTSPSVNGRSYD---------------- 384

  Fly   594 QSTSSSGNQHSHSHSNPHDMLANLNNSLINP 624
              |.:..:..:|.:|.|.......:..||:|
  Rat   385 --TYTPPHMQTHMNSQPMGTSGTTSTGLISP 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	19/52 (37%)
Pax6	XP_006234695.1	PAX	4..142	CDD:128645
Pax6	XP_006234695.1	Homeobox	228..281	CDD:395001	19/52 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910