DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lmx1a and ABLIM3

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001287944.1	Gene:	ABLIM3 / 22885	HGNCID:	29132	Length:	683	Species:	Homo sapiens

Alignment Length:	340	Identity:	76/340 - (22%)
Similarity:	118/340 - (34%)	Gaps:	67/340 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CEGCGQKI-HDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCC 338
            |.||.::| |.:.|:.: |..||..|..|..|.:.|......::...||:.||...||:||.:|.
Human   151 CAGCKEEIKHGQSLLAL-DKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHAQFGIKCETCD 214

  Fly   339 HAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQH 403
            ..|..:.|   ......:|..|..|..|.....:||                  ||:|..:...|
Human   215 RYISGRVL---EAGGKHYHPTCARCVRCHQMFTEGE------------------EMYLTGSEVWH 258

  Fly   404 --CGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALA--KDTGLS 464
              |......|:.|...|........|.:.:.|..|           ..|.||...:.  ||....
Human   259 PICKQAARAEKKLKHRRTSETSISPPGSSIGSPNR-----------VICAKVDNEILNYKDLAAL 312

  Fly   465 VRVVQVWFQNQRAKMKKIQRKAKQNGG---SGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELG 526
            .:|..: ::.||..:...:..::....   ...|.|...||.:..:.|..:..|...:      .
Human   313 PKVKSI-YEVQRPDLISYEPHSRYMSDEMLERCGYGESLGTLSPYSQDIYENLDLRQR------R 370

  Fly   527 GDSSGYLGGLDS-TFASQPLNPNLPFSPDDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNN 590
            ..|.||   :|| |::.|.::|....||..|..:..:|..||..      ..|||..:.:
Human   371 ASSPGY---IDSPTYSRQGMSPTFSRSPHHYYRSGPESGRSSPY------HSQLDVRSST----- 421

  Fly   591 LELQSTSSSGNQHSH 605
                .||....:|.|
Human   422 ----PTSYQAPKHFH 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	16/52 (31%)
		LIM	333..388	CDD:295319	11/54 (20%)
		Homeobox	427..480	CDD:278475	11/54 (20%)
ABLIM3	NP_001287944.1	LIM1_abLIM	23..74	CDD:188713
		LIM2_abLIM	79..134	CDD:188714
		LIM3_abLIM	151..202	CDD:188715	15/51 (29%)
		LIM4_abLIM	210..265	CDD:188716	15/75 (20%)
		AbLIM_anchor	274..647	CDD:292800	39/195 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..472		21/79 (27%)
		VHP	648..683	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910