DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and FHL3

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_004459.2	Gene:	FHL3 / 2275	HGNCID:	3704	Length:	280	Species:	Homo sapiens

Alignment Length:	121	Identity:	36/121 - (29%)
Similarity:	49/121 - (40%)	Gaps:	8/121 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 CEKNFELCEGCGQKI--HDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKL-YCKMDYDRL 329
            |......|..||:.:  ..|.| ..|...|||.|..|..|...|....:|.:... ||...|:..
Human    94 CSAFSSQCSACGETVMPGSRKL-EYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENK 157

  Fly   330 FGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFC 385
            |..:|:.|...:....:..|..|   :|..|.||..|:.|| .|:||..||...:|
Human   158 FAPRCARCSKTLTQGGVTYRDQP---WHRECLVCTGCQTPL-AGQQFTSRDEDPYC 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	16/54 (30%)
		LIM	333..388	CDD:295319	17/53 (32%)
		Homeobox	427..480	CDD:278475
FHL3	NP_004459.2	LIM	<5..33	CDD:295319
		LIM1_FHL3	36..94	CDD:188807	36/121 (30%)
		LIM2_FHL3	98..155	CDD:188811	16/57 (28%)
		LIM3_FHL	162..213	CDD:188732	17/52 (33%)
		LIM4_FHL3	221..276	CDD:188818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910