DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and FHL2

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001034581.1	Gene:	FHL2 / 2274	HGNCID:	3703	Length:	279	Species:	Homo sapiens

Alignment Length:	113	Identity:	34/113 - (30%)
Similarity:	51/113 - (45%)	Gaps:	4/113 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 CEGCGQKIH-DRFLMNVGDANWHEQCLACCYCGMQLHHTCY-VRNSKLYCKMDYDRLFGVKCSSC 337
            ||.||:.|. |...::..|.:|||.|..|..|...|....: .:..:|.|...|...:..||..|
Human    40 CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQEC 104

  Fly   338 CHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFC 385
            ...|:|....|. .....:|..||:|:.|:.|:.. :.|:.:|.|.||
Human   105 KKTIMPGTRKME-YKGSSWHETCFICHRCQQPIGT-KSFIPKDNQNFC 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	16/53 (30%)
		LIM	333..388	CDD:295319	17/53 (32%)
		Homeobox	427..480	CDD:278475
FHL2	NP_001034581.1	LIM	<5..33	CDD:413332
		LIM1_FHL2	36..97	CDD:188806	17/56 (30%)
		LIM2_FHL2	101..157	CDD:188810	16/52 (31%)
		LIM3_Fhl2	162..218	CDD:188815
		LIM4_FHL2	221..278	CDD:188817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910