DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and FHL1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006724806.1	Gene:	FHL1 / 2273	HGNCID:	3702	Length:	339	Species:	Homo sapiens

Alignment Length:	198	Identity:	46/198 - (23%)
Similarity:	67/198 - (33%)	Gaps:	44/198 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 KC--EKNFELCEGCGQKIHDRFLMNVGDAN-------WHEQCLACCYCGMQL-HHTCYVRNSKLY 321
            ||  .::...|:||.:.|      ..||.|       ||:.|..|..|...: ..:.:.:....|
Human   107 KCTTREDSPKCKGCFKAI------VAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFY 165

  Fly   322 CKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCY 386
            |...::..|...|..|..||....:..:..|   :|..||||..|...| .|::|...:.|.:|.
Human   166 CVTCHETKFAKHCVKCNKAITSGGITYQDQP---WHADCFVCVTCSKKL-AGQRFTAVEDQYYCV 226

  Fly   387 RHDLEKEMFLAAAAAQHCGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCR 451
              |..|..     .|:.|.                 |.|.|.|...:..|.....|..:.|..|.
Human   227 --DCYKNF-----VAKKCA-----------------GCKNPITGKRTVSRVSHPVSKARKPPVCH 267

  Fly   452 KVR 454
            ..|
Human   268 GKR 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	14/59 (24%)
		LIM	333..388	CDD:295319	16/54 (30%)
		Homeobox	427..480	CDD:278475	7/28 (25%)
FHL1	XP_006724806.1	LIM	<21..49	CDD:413332
		LIM1_FHL1	56..109	CDD:188730	1/1 (100%)
		LIM2_FHL1	117..174	CDD:188808	14/62 (23%)
		LIM3_FHL1	178..230	CDD:188813	17/57 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910