DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Ablim1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_848803.3	Gene:	Ablim1 / 226251	MGIID:	1194500	Length:	861	Species:	Mus musculus

Alignment Length:	441	Identity:	89/441 - (20%)
Similarity:	133/441 - (30%)	Gaps:	149/441 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 ASAAAASKLSADCSGRTEVGHIKCEKNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQL 309
            |...::|...|.||..              |.|||:.|.:...:...|..||..|..|..||..|
Mouse   210 AQPMSSSPKEASCSSN--------------CAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVL 260

  Fly   310 HHTCYVRNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGE 374
            ......::...||:.||..||||||.: ||..:..:::.....:  :|..|..|..|.....:||
Mouse   261 TGEYISKDGSPYCEKDYQGLFGVKCEA-CHQFITGKVLEAGDKH--YHPSCARCSRCNQMFTEGE 322

  Fly   375 QFMLRDGQLFCYRHDLEKEMFLAAAAAQH--CGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRK 437
                              ||:|..:...|  |. .....|:.|||      |..||:.......|
Mouse   323 ------------------EMYLQGSTVWHPDCK-QSTKTEEKLRP------PNIPRSSSDFFYPK 362

  Fly   438 QFKASFDQSP------KPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGS 496
            .......:||      .||                     ..|.....::..|.:.::..|..||
Mouse   363 SLIRRTGRSPALQLLSPPC---------------------LMNSNKNPRQPTRTSSESIYSRPGS 406

  Fly   497 GSGRGTG-------NSSATDDKD-------------------------TNDKEDKCVKQELG--- 526
            ......|       ::...|.||                         |:..|||..:|.||
Mouse   407 SIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQERQSLGESP 471

  Fly   527 ------GDSSGY-------------LGGLDSTFASQPLNPNLPFSPDDYPANSNDSFCSSDLSLD 572
                  ..:.||             .|.::|     |:.....::|.  .:.|...|...:|...
Mouse   472 RTLSPTPSAEGYQDVRDRMIHRSTSQGSINS-----PVYSRHSYTPT--TSRSPQHFHRPELLSP 529

  Fly   573 GSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNP---HDMLANLNNS 620
            |              ::......|||..:.||.|..||   |..|.::..:
Mouse   530 G--------------VHRWSPLRTSSFSSTHSDSRPNPPFRHHFLPHVKGN 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	16/51 (31%)
		LIM	333..388	CDD:295319	10/54 (19%)
		Homeobox	427..480	CDD:278475	8/58 (14%)
Ablim1	NP_848803.3	LIM1_abLIM	99..150	CDD:188713
		LIM2_abLIM	155..210	CDD:188714	89/441 (20%)
		LIM3_abLIM	226..277	CDD:188715	15/50 (30%)
		LIM4_abLIM	285..340	CDD:188716	14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..414		7/60 (12%)
		AbLIM_anchor	394..825	CDD:292800	35/194 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..590		26/129 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	634..682
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..748
		VHP	826..861	CDD:128458
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910