DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Nkx2-6

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_035050.2	Gene:	Nkx2-6 / 18092	MGIID:	97351	Length:	289	Species:	Mus musculus

Alignment Length:	170	Identity:	49/170 - (28%)
Similarity:	67/170 - (39%)	Gaps:	27/170 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 VGLDEEDLLR--PRDGRRGPKRPRTILTSQ-QRKQFKASFDQSPKPCRKVREALAKDTGLSVRVV 468
            ||....|:.|  |...|..|:|...:|.|| |....:..|.|........||.||....|:...|
Mouse   103 VGNLSGDMRRGGPVSTRTRPQRKSRVLFSQAQVLALERRFKQQRYLTAPEREHLASALQLTSTQV 167

  Fly   469 QVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSS--- 530
            ::||||:|.|.|. ||:.:....:|......|........|.|...|.:   |...||...:
Mouse   168 KIWFQNRRYKSKS-QRQDQTLELAGHPLAPRRVAVPVLVLDGKPCLDPD---VAAFLGPYKATSP 228

  Fly   531 -----GYLG-GLDSTFASQ---------PLNP--NLPFSP 553
                 ||.| ..|:::||:         ||.|  :..|||
Mouse   229 YSCFGGYAGTPYDASYASRCTSASAGPGPLTPLASSGFSP 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	18/53 (34%)
Nkx2-6	NP_035050.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..125		7/21 (33%)
		Homeobox	126..179	CDD:278475	18/52 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..289		4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910