DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and DLX4

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_612138.1	Gene:	DLX4 / 1748	HGNCID:	2917	Length:	240	Species:	Homo sapiens

Alignment Length:	215	Identity:	52/215 - (24%)
Similarity:	70/215 - (32%)	Gaps:	71/215 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   352 PNFVFHLPC--FVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCG-------FV 407
            ||..:..|.  .:.|....|...|      |..|.|.:.        ||.:...||       ..
Human    43 PNLSYSRPYGHLLSYPYTEPANPG------DSYLSCQQP--------AALSQPLCGPAEHPQELE 93

  Fly   408 GLDEEDLLRPRDGRRGP-------KRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSV 465
            ...|:..|.|....|.|       ::||||.:|.|.:.....|..:.......|..||...||:.
Human    94 ADSEKPRLSPEPSERRPQAPAKKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQ 158

  Fly   466 RVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSS 530
            ..|::||||:|:|.||:   .|||.|...|...||
Human   159 TQVKIWFQNKRSKYKKL---LKQNSGGQEGDFPGR------------------------------ 190

  Fly   531 GYLGGLDSTFASQPLNPNLP 550
                    ||:..|.:|.||
Human   191 --------TFSVSPCSPPLP 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319	9/37 (24%)
		Homeobox	427..480	CDD:278475	19/52 (37%)
DLX4	NP_612138.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..120		7/39 (18%)
DLX4	NP_612138.1	Homeobox	120..173	CDD:306543	19/52 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910