DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and DLX1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_835221.2	Gene:	DLX1 / 1745	HGNCID:	2914	Length:	255	Species:	Homo sapiens

Alignment Length:	118	Identity:	34/118 - (28%)
Similarity:	54/118 - (45%)	Gaps:	3/118 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 KRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQN 489
            ::||||.:|.|.:.....|.|:.......|..||...||:...|::||||:|:|.||:.   ||.
Human   129 RKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLM---KQG 190

  Fly   490 GGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFAS 542
            |.:..||....|...|:.:.........:....:..||::..|:....|.:.|
Human   191 GAALEGSALANGRALSAGSPPVPPGWNPNSSSGKGSGGNAGSYIPSYTSWYPS 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	20/52 (38%)
DLX1	NP_835221.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..118
		Homeobox	131..185	CDD:395001	20/53 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..230		3/25 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910