DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Lmx1b

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006497809.1	Gene:	Lmx1b / 16917	MGIID:	1100513	Length:	408	Species:	Mus musculus

Alignment Length:	387	Identity:	155/387 - (40%)
Similarity:	207/387 - (53%)	Gaps:	61/387 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 LCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCC 338
            :||||.:.|.|||||.|.:::|||:||.|..|...|..:||.|:.|||||.||.:||..|||.|.
Mouse    61 VCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLYCKQDYQQLFAAKCSGCM 125

  Fly   339 HAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEM-FLAAAAAQ 402
            ..|.|.|.|||.: ..|:||.||.|..|...|:||::|:|::|||.| :.|.|||. .|::.:..
Mouse   126 EKIAPTEFVMRAL-ECVYHLGCFCCCVCERQLRKGDEFVLKEGQLLC-KGDYEKEKDLLSSVSPD 188

  Fly   403 HCGFVGLDEED-LLRPRDGR--------------RGPKRPRTILTSQQRKQFKASFDQSPKPCRK 452
            ....|..::|| .::|..|:              |.|||||||||:|||:.|||||:.|.|||||
Mouse   189 ESDSVKSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKASFEVSSKPCRK 253

  Fly   453 VREALAKDTGLSVRVVQVWFQNQRAKMKKI-----QRKAKQNGGSGGGSG-SGRGTGNSSATDDK 511
            |||.||.:|||||||||||||||||||||:     |::.:||....|... |.|..|..::....
Mouse   254 VRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPL 318

  Fly   512 DTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYPANSNDSFCSSDLSLDGSNF 576
            ....::...::|...|.|..:..||..        |.:|  .|......|||.           |
Mouse   319 APPQQQIVAMEQSPYGSSDPFQQGLTP--------PQMP--GDHMNPYGNDSI-----------F 362

  Fly   577 DQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNPHDMLANLNNSLINPIDKLYLMQNSYFSS 638
            ..:|.|....||::..|.|:.                :.:|...:.||||:||.||:|||:|
Mouse   363 HDIDSDTSLTSLSDCFLGSSD----------------VGSLQARVGNPIDRLYSMQSSYFAS 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	28/51 (55%)
		LIM	333..388	CDD:295319	26/54 (48%)
		Homeobox	427..480	CDD:278475	43/52 (83%)
Lmx1b	XP_006497809.1	LIM1_Lmx1b	62..114	CDD:188757	28/51 (55%)
		LIM2_Lmx1a_Lmx1b	121..175	CDD:188764	25/55 (45%)
		Homeobox	228..282	CDD:365835	44/53 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9112
eggNOG	1	0.900	-	-		E33208_3BAC6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3240
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323174at33208
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	1	1.000	-	-		otm43918
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	O	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X1182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760