Protein Alignment Lmx1a and NKX2-3

DIOPT Version :9

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_660328.2
• Gene: NKX2-3 / 159296
• HGNCID: 7836
• Length: 364
• Species: Homo sapiens
• Alignment Length: 225
• Identity: 56/225 - (24%)
• Similarity: 79/225 - (35%)
• Gaps: 75/225 - (33%)

  Fly    72 LTGQHQQHQQQQHQQQQQH---PHQQH------------------------QQHQQQ------HA 103
            |..|.|..:.::..:||::   |.::|                        :|.|.:      ||
Human   154 LFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHA 218

  Fly   104 ASTTP----VPI-----NSCPTPTGH---SPLSSSSSNSNHNNNNNNNNGGSSSNNLHSACNTLT 156
            ....|    ||:     ..|.||:..   :|.|..:|..::|:......|           |:..
Human   219 PPPPPRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYNSFPAYGYG-----------NSAA 272

  Fly   157 AAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAAAAAAAAATTPTSTGPAATGSG------ 215
            |||.|||:|||.||.|        |..|.|..|.........:||||......:|.|.|
Human   273 AAAAAAAAAAAAAAYS--------SSYGCAYPAGGGGGGGGTSAATTAMQPACSAAGGGPFVNVS 329

  Fly   216 NANGSGNGNGNGNGNGNGNGNGNGGGAATA 245
            |..|.|:|     |:......|...|||.|
Human   330 NLGGFGSG-----GSAQPLHQGTAAGAACA 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475
NKX2-3	NP_660328.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..153
		HOX	148..204	CDD:197696	7/49 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910