DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and PRICKLE1

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001138353.1	Gene:	PRICKLE1 / 144165	HGNCID:	17019	Length:	831	Species:	Homo sapiens

Alignment Length:	468	Identity:	108/468 - (23%)
Similarity:	156/468 - (33%)	Gaps:	135/468 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 LCEGCGQKIHDR----FLMNVG-DANWHEQCLACCYCGMQLHHTCY-VRNSKLYCKMDYDRLFGV 332
            :||.||.||:..    |....| ...||..|..|..|...|....| .::.|::|...:..|...
Human   125 VCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKP 189

  Fly   333 KCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMF-- 395
            :||:|...|...|..  ......:|:..|.|..|...| .|::::::||:.||.      ..|
Human   190 RCSACDEIIFADECT--EAEGRHWHMKHFCCLECETVL-GGQRYIMKDGRPFCC------GCFES 245

  Fly   396 LAAAAAQHCG-FVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSP-----------K 448
            |.|...:.|| .:|:|...:  ..||:...........:    |.|||....|           |
Human   246 LYAEYCETCGEHIGVDHAQM--TYDGQHWHATEACFSCA----QCKASLLGCPFLPKQGQIYCSK 304

  Fly   449 PCRKVREALAKDTGLSVRVVQVWFQNQRA-------KMKKIQRKAKQ-----------NGGSGGG 495
            .|....:..|.|:..|.      ||:.|:       :|.|..|.|.|           |....|.
Human   305 TCSLGEDVHASDSSDSA------FQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGL 363

  Fly   496 SGSGRGT-------------GNSSATDD-----KDTNDKEDKCVKQELGGDSSGYLG------GL 536
            ||:...|             |.|.|:::     .:....||    .|...|...|:.      |.
Human   364 SGNADDTLSRKLDDLSLSRQGTSFASEEFWKGRVEQETPED----PEEWADHEDYMTQLLLKFGD 424

  Fly   537 DSTFASQP-----------LNPNLPFSPDDYPANSNDSFCS----SDL----SLDG---SNFDQL 579
            .|.|..||           ::.|:..|..:...| |.|..|    ||:    |.||   |.:...
Human   425 KSLFQPQPNEMDIRASEHWISDNMVKSKTELKQN-NQSLASKKYQSDMYWAQSQDGLGDSAYGSH 488

  Fly   580 DDDADSLSLNNLELQSTSSSGNQHSH-----------SHSNPHD---------MLANLNNSLIN- 623
            ...|.|..|..|||.. .:||..|..           |...|..         .|:|:..:.::
Human   489 PGPASSRRLQELELDH-GASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDG 552

  Fly   624 ---PIDKLYLMQN 633
               |...||.:||
Human   553 ENKPRPSLYSLQN 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	17/57 (30%)
		LIM	333..388	CDD:295319	15/54 (28%)
		Homeobox	427..480	CDD:278475	13/70 (19%)
PRICKLE1	NP_001138353.1	PET_Prickle	22..118	CDD:193602
		LIM1_Prickle_1	126..184	CDD:188867	17/57 (30%)
		LIM2_Prickle	189..244	CDD:188802	15/63 (24%)
		LIM3_Prickle	249..307	CDD:188804	12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..342		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..688
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910