DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and AgaP_AGAP005138

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_314022.4	Gene:	AgaP_AGAP005138 / 1274816	VectorBaseID:	AGAP005138	Length:	456	Species:	Anopheles gambiae

Alignment Length:	511	Identity:	177/511 - (34%)
Similarity:	237/511 - (46%)	Gaps:	119/511 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 STTPVPINS-CPTPTGHSPLSSSSSNSNHNNNNNNNNGGS--SSNNL-----------HSACNTL 155
            |:..|||.| |...........|.:|:.|.|..|..|.|:  ::.|.           :|:|:..
Mosquito     2 SSVSVPIESKCSAGQPEPDTGGSLTNNEHANGTNGVNIGANVTAGNTATPGPGMIPGSNSSCSAK 66

  Fly   156 TAAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAAAAAAAAATTPTSTGPAATGSGNANGS 220
            |  .:.......:....|..:..|.:..||:|.||..|.......|...|:            ||
Mosquito    67 T--PITTTGTPTLQPSVPRSSQQAYTTTGGSVTAATLAEGQRLLLAAVMTA------------GS 117

  Fly   221 GNGNGNGNGNGNGNGNGNGGGAATASAAAASKLSADCSGRTEVGHIKCEKNFELCEGCGQKIHDR 285
            |||........:|:|:|..|....|.....|                      ||..|...|.||
Mosquito   118 GNGEIGAQQQQHGDGSGGDGPEHLAGLLGTS----------------------LCGQCCGPICDR 160

  Fly   286 FLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFG-VKCSSCCHAILPQELVMR 349
            ::|.|.|..:||:||.|..|.::|.|:|::|:.||||:.||:||:| .:|..|...|...|||||
Mosquito   161 YIMKVVDITYHERCLQCTSCSIRLMHSCFMRDGKLYCRFDYERLYGRNRCLGCGEKIGADELVMR 225

  Fly   350 PIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEK--EMFLAAAAAQHCGFVGLDEE 412
            .:.| ||||.||:|..|.:.||||:|::::..|||| |.|.||  |||...:...:|.      :
Mosquito   226 ALDN-VFHLKCFICVVCGVRLQKGDQYVIKQSQLFC-RPDYEKEVEMFQGYSYDDYCC------D 282

  Fly   413 DLLRPR-DGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQR 476
            |:.:.| ||||||||||||||:|||:.||||||.|||||||:||.||||||||:|:||
Mosquito   283 DMFQTRIDGRRGPKRPRTILTTQQRRAFKASFDISPKPCRKIREGLAKDTGLSIRIVQ------- 340

  Fly   477 AKMKKIQRKAKQNGGS----GGGSGS--------GRGTGNSSATDDKDT-------------NDK 516
                |||:|..:.||.    |||:||        |.|.||.|..:..|.             ::.
Mosquito   341 ----KIQKKQLKEGGKSSHHGGGNGSSGGNKNHNGNGKGNDSQEELSDNESAVGGKLSLRIKDEN 401

  Fly   517 EDKCV------------KQELGGDSSGYLGGLDSTFAS--QPLNPNLPFSPDDYPA 558
            ..||.            ||  ||.|..:.....|.||:  |.::|     |...||
Mosquito   402 SSKCTNCFALSRSLRPGKQ--GGRSQFFTSTTSSWFATSVQRISP-----PAHTPA 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	23/51 (45%)
		LIM	333..388	CDD:295319	26/54 (48%)
		Homeobox	427..480	CDD:278475	35/52 (67%)
AgaP_AGAP005138	XP_314022.4	LIM	150..202	CDD:295319	23/51 (45%)
		LIM	210..264	CDD:295319	27/55 (49%)
		homeodomain	296..>341	CDD:238039	37/55 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAC6
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143053at6656
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1182
TreeFam	0	0.000	Not matched by this tool.
	5	4.820