DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and AgaP_AGAP005096

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_313972.3	Gene:	AgaP_AGAP005096 / 1274771	VectorBaseID:	AGAP005096	Length:	898	Species:	Anopheles gambiae

Alignment Length:	733	Identity:	160/733 - (21%)
Similarity:	220/733 - (30%)	Gaps:	268/733 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPVGGSLYSLQ----QNHGGARFLDNPNPGSMTASSGNSL---------HLSNSNNNLPTSISGN 63
            :|.....|..|    |:|  .:.||.....|:..||..|.         ||.:.:|        :
Mosquito   140 SPSSPDKYQQQLANYQSH--IKSLDLVAASSLEPSSPQSALHHQLPSHHHLHHHHN--------H 194

  Fly    64 NSPTATASL---TGQHQQH------QQQQHQQQQQHPHQQHQQHQQQHAASTTPVPINSCPTPTG 119
            ..|.|...|   ...||.|      ||..||||||..||||..||              .|:||
Mosquito   195 QHPPAVPHLHQHAAHHQHHHAHNHLQQHLHQQQQQQQHQQHLPHQ--------------LPSPT- 244

  Fly   120 HSPLSSSSSNSNHNNNNNNNNGGSSSNNLHSACNTLTAAAVAAASAAAVAAPSPAGTSVATSQ-- 182
                                         |.:.:.|   |:..|...|:....|...|:|..:
Mosquito   245 -----------------------------HPSQHQL---ALHHAQHPALGQQQPPHPSLAELEYM 277

  Fly   183 -----------------LGGAVAAAIAAAAAAAAAATTPTSTGPAATGSG-------NANGSGNG 223
                             ||  .||.:...........|.||.|..|:|.|       :..|:|:|
Mosquito   278 KTLKETNKYFIDRNYRSLG--YAAGMRGGPEGPPEDGTGTSAGGGASGGGEYEENLSSPTGAGSG 340

  Fly   224 NGNG----------NGNGNGNGN-GNGGGAATASAAAASKLSADCSGRTEVGHIKCEKNFELCEG 277
            ||:|          :|.....|| |||.|.......:.|..::|.|         ..|..:|.|.
Mosquito   341 NGSGSLKRKYDRTRDGEDRPGGNGGNGDGGVLLPDGSESNPTSDSS---------INKYNKLHES 396

  Fly   278 CGQKIHDR---FLMNVGDANWHEQCLACCYCGMQLHH--------------TCYVRNSKLYCKMD 325
            ..:.|...   ::.|..:....:   |..|...|.||              ...|.:.:...:..
Mosquito   397 ADKSIRANSFDYMKNFDELRARQ---AAAYEAEQHHHHHQQQQQQQQHHHQQLQVLHQQQQQQQT 458

  Fly   326 YDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYA-------CRLPLQKGEQFMLRDGQL 383
            ...|     |...|   ||:    |.|:...|.......|       .|.....|......||.:
Mosquito   459 QQHL-----SQSQH---PQQ----PSPSSGQHGTTAGTNAGTDDYNPHRQSADSGADKGADDGGV 511

  Fly   384 FCYRHDLEKEMFLAAAAAQHCGFVGLDEE---DLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQ 445
             .|....|.....::...:..| .|.|:|   |....:..||.    ||..|:.|..:.:.:|::
Mosquito   512 -SYASSEELNQTTSSEQGEKVG-SGSDDEGGDDNCSKKKHRRN----RTTFTTYQLHELERAFEK 570

  Fly   446 SPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQ-----------------NGGSG 493
            |..|....||.||....|....|||||||:|||.:: |.|::.                 |||
Mosquito   571 SHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRR-QEKSESLRLGLSHFSQLPHRLSCNGG-- 632

  Fly   494 GGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNLPFSPDDYPA 558
                                |...|..:...|.....|:|                     .:|.
Mosquito   633 --------------------NLPVDPWLSPPLLSALPGFL---------------------SHPQ 656

  Fly   559 NSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLEL-------------QS----TSSSGNQHSHS 606
            ....|:.:..|||:.||          |.:.||.|             ||    ||......|..
Mosquito   657 GVYPSYLTPPLSLNPSN----------LGMTNLGLGHPNGPQNLRISPQSMAAMTSPQMTAGSMR 711

  Fly   607 HSNPHDMLANLNNSLINP 624
            .|.||     :|.||..|
Mosquito   712 LSPPH-----VNGSLGGP 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	9/68 (13%)
		LIM	333..388	CDD:295319	13/61 (21%)
		Homeobox	427..480	CDD:278475	22/52 (42%)
AgaP_AGAP005096	XP_313972.3	Homeobox	553..605	CDD:278475	22/51 (43%)
AgaP_AGAP005096	XP_313972.3	OAR	870..886	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910