DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and Lmx1a

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_387501.1	Gene:	Lmx1a / 110648	MGIID:	1888519	Length:	382	Species:	Mus musculus

Alignment Length:	425	Identity:	162/425 - (38%)
Similarity:	215/425 - (50%)	Gaps:	99/425 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 IKCEKNFE---------------------LCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQL 309
            :|.|:||:                     :||||.:.|.||||:.:.|:.|||||:.|..|...|
Mouse     5 LKMEENFQSAIETSASFSSLLGRAVSPKSVCEGCQRVISDRFLLRLNDSFWHEQCVQCASCKEPL 69

  Fly   310 HHTCYVRNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGE 374
            ..||:.|:.|||||..|::||.|||..|..||.|.|.||| ....|:||.||.|..|...||||:
Mouse    70 ETTCFYRDKKLYCKYHYEKLFAVKCGGCFEAIAPNEFVMR-AQKSVYHLSCFCCCVCERQLQKGD 133

  Fly   375 QFMLRDGQLFCYRHDLEKE---MFLAAAAAQHCGFVGLDEEDLLR---------PRDGR--RGPK 425
            :|:|::|||.| :.|.|||   :.|.:.||...| ...|||.|.:         ..||:  :.||
Mouse   134 EFVLKEGQLLC-KGDYEKERELLSLVSPAASDSG-KSDDEESLCKSAHGAGKGASEDGKDHKRPK 196

  Fly   426 RPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNG 490
            |||||||:|||:.|||||:.|.||||||||.||.:|||||||||||||||||||||:.|:.:|
Mouse   197 RPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQ-- 259

  Fly   491 GSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNL------ 549
                           ...|.::|    .:....:..|..:..:.|:.:.:.:.|....|
Mouse   260 ---------------QQQDQQNT----QRLTSAQTNGSGNAGMEGIMNPYTTLPTPQQLLAIEQS 305

  Fly   550 -----PF----SPDDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLE--LQSTSSSGNQH 603
                 ||    :|...|.:....:.:..|      |..|  |:|..||:||.  ..:||.:|
Mouse   306 VYNSDPFRQGLTPPQMPGDHMHPYGAEPL------FHDL--DSDDTSLSNLGDCFLATSEAG--- 359

  Fly   604 SHSHSNPHDMLANLNNSLINPIDKLYLMQNSYFSS 638
                        .|.:.:.||||.||.||||||:|
Mouse   360 ------------PLQSRVGNPIDHLYSMQNSYFTS 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	26/51 (51%)
		LIM	333..388	CDD:295319	27/54 (50%)
		Homeobox	427..480	CDD:278475	43/52 (83%)
Lmx1a	NP_387501.1	LIM1_Lmx1a	35..86	CDD:188756	26/50 (52%)
		LIM2_Lmx1a_Lmx1b	94..148	CDD:188764	25/56 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..208		35/46 (76%)
		Homeobox	198..252	CDD:365835	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..286		4/33 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9112
eggNOG	1	0.900	-	-		E33208_3BAC6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3240
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001820
OrthoInspector	1	1.000	-	-		otm43918
orthoMCL	1	0.900	-	-		OOG6_105498
Panther	1	1.100	-	-	LDO	PTHR24208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3844
SonicParanoid	1	1.000	-	-		X1182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850