Protein Alignment Lmx1a and Isl2

DIOPT Version :10

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: XP_006510819.1
• Gene: Isl2 / 104360
• MGIID: 109156
• Length: 370
• Species: Mus musculus
• Alignment Length: 351
• Identity: 112/351 - (31%)
• Similarity: 163/351 - (46%)
• Gaps: 59/351 - (16%)

  Fly   257 CSGRTEVGHIKCEKNFE-----LCEGCGQKIHDRFLMNVG-DANWHEQCLACCYCGMQLHH--TC 313
            |||..:: .::.::|.|     :|.|||.:|||:|::.|. |..||..||.|..|...|..  ||
Mouse    16 CSGTWKM-VLQRQRNGEKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTC 79

  Fly   314 YVRNSKLYCKMDYDRLFGVKCSSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFML 378
            :||:.|.|||.||.||||:||:.|.......:|||| ..:.|:|:.||.|..|...|..|::|.|
Mouse    80 FVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLVMR-ARDSVYHIECFRCSVCSRQLLPGDEFSL 143

  Fly   379 RDGQLFCYRHD----LEKEMF--------LAAAAAQHCGFVGLDEEDLLRPRDGRRGPK--RPRT 429
            |:.:|.| |.|    ||:...        |..|...|....|...:..||....::..|  |.||
Mouse   144 REHELLC-RADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPSLRTHVHKQAEKTTRVRT 207

  Fly   430 ILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAK-------MKKIQR--- 484
            :|..:|....:..:..:|:|...::|.|.:.||||.||::|||||:|.|       ||::|:
Mouse   208 VLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQH 272

  Fly   485 --KAKQNGGSGGGSGSGRGTGNSSATDDKDT------------------NDKEDKCVKQELGGDS 529
              ||...|.:|....:|....:.:|......                  :|.:....:|.:....
Mouse   273 SDKASLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSE 337

  Fly   530 SGYLG---GLDSTFASQPLNPNLPFS 552
            ||.||   |.|.|..|..| |:.|.|
Mouse   338 SGSLGNSSGSDVTSLSSQL-PDTPNS 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	26/54 (48%)
		LIM	333..388	CDD:413332	20/54 (37%)
		Homeodomain	425..481	CDD:459649	24/64 (38%)
Isl2	XP_006510819.1	LIM1_Isl	38..92	CDD:188752	25/53 (47%)
		LIM2_Isl2	100..154	CDD:188855	20/55 (36%)
		HOX	202..258	CDD:197696	22/55 (40%)