DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and tmem143

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_031762409.1	Gene:	tmem143 / 100496619	XenbaseID:	XB-GENE-6044161	Length:	507	Species:	Xenopus tropicalis

Alignment Length:	248	Identity:	49/248 - (19%)
Similarity:	82/248 - (33%)	Gaps:	56/248 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 LDEEDLLRPRDGRRGPKRPRTILTSQQRKQF-----KASFDQSPKPCRKVREALAKDTGLS---V 465
            |..:....|::......:.|..:|...:.:|     |....|.|...|: |...|....:|   :
Frog    19 LQTQSFFSPQENSCQSGKVRACVTDSLKLRFLSFQPKGRHSQWPAGARR-RYCAAAGLNVSPAPI 82

  Fly   466 RVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGTGNSSA-----------TDDKD-TNDKED 518
            .|:.:.|......:..::.      .||.|..:.||.|..:|           .:.|| |...::
Frog    83 EVIALSFIMLYTTLGAVRI------ASGIGIPAARGMGTLAAKMAEYRKMWKPIEPKDWTVQYQE 141

  Fly   519 KCVK-----------QELGGDSS---GYLGGLDSTFAS--QPLNPNL--------PFSPDDYPAN 559
            :.:.           ||:..|.|   .:|..:|....|  ||.:..|        |.:||.....
Frog   142 RYIPLSKGQIVEHLIQEIHCDKSERQSFLSFVDQLEHSLFQPYHSTLEALQLLYDPINPDRDATL 206

  Fly   560 SNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSNPHD 612
            ......|..|..:....|||....|..:.|.|...:.:.:...|     :|||
Frog   207 ETPLLDSEKLLKEKEVLDQLQPVLDQANFNVLSEDALAYALIVH-----HPHD 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	12/60 (20%)
tmem143	XP_031762409.1	DUF3754	298..422	CDD:403691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910