DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and zfhx3

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_002937624.2	Gene:	zfhx3 / 100495855	XenbaseID:	XB-GENE-853731	Length:	3619	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	154/808 - (19%)
Similarity:	224/808 - (27%)	Gaps:	327/808 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QNHGGARFLDNPNPGSMTASS-----GNSLHLSNSNNNLPTSISGNNSPTATASLTGQHQ----- 77
            ||.......|...|.|.|.|:     ..|..:|:|:|...|....:.:......|:.:.:
Frog  2341 QNEDSTDATDLLTPSSSTCSTPMTFPSFSTAVSSSSNTSCTPFLQHTTDAEDIILSSKSEASHDD 2405

  Fly    78 --QH------QQQQHQQQQQHPHQQHQQ------HQQQHAASTTPVPINSCPTPTGHSPLSSSSS 128
              :|      ||.|.|:|.|.|.|:.||      |..||..:...:.:    ||..::||.|||:
Frog  2406 KPKHFEPIRTQQNQTQEQPQQPKQESQQPQSTQSHPLQHDQAEDKMSV----TPQKNAPLPSSSA 2466

  Fly   129 NS-----NHNNNNNNNNGGSSSNNLHSA-----CNTLTAAAVAAASAAAVAAPS----------- 172
            ..     ...:.|.......|...||::     .|..............:|.||
Frog  2467 QPPQCTVTQTSPNTTQISQFSIKPLHTSSPQQLANIPPPLLPYQCDQCKLAFPSFEHWQEHQQLH 2531

  Fly   173 --------------------------PAGTSVATSQLGGAVAAAIAAAAAAAAAATTPTST---- 207
                                      |:...:|:..|.|.::   .....:|.:.:||:||
Frog  2532 FLSAQNQFIHPQFLDRSMDMPFMLFDPSNPLLASQLLSGGLS---QIPPGSATSPSTPSSTMNTL 2593

  Fly   208 ----GPAATGSGNANGSGNGNGNGNGN-------------------------------------- 230
                ...|..|...|.||.|......:
Frog  2594 KRKLEEKANASPGENDSGTGGEEPQRDKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVG 2658

  Fly   231 ----------GNGNGNGNGGGAATASAAAASKLSADC----SGRTEV-GHIKCEK---------N 271
                      .|.......|.......|.|.:....|    ..:|.: .||:...         |
Frog  2659 LKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYN 2723

  Fly   272 FEL------CEGCGQKIHDRFLMNVG-----DANWHEQCLACC--YCGMQLHHTCYVRNSKLYCK 323
            ..|      |:|.  ::...|..|.|     .::...||::..  ...|:|.....:..|.:..:
Frog  2724 MNLSAMLIDCDGI--QLKGDFFDNTGFNSLPHSSGDGQCISFSPGSKSMELSPRTLLSPSSIKVE 2786

  Fly   324 ----------------MDYDRLFGVKCSSCCHAI------------------------------- 341
                            .|..:|....|||...||
Frog  2787 GVEDFESPSMSSVNLSFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSTTGIIAETKSISLNSD 2851

  Fly   342 -LPQ--------------ELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLE 391
             ||:              ..::.|.|::                               |..:.|
Frog  2852 GLPKSGMITMSEYEDQMSSGLVSPAPSY-------------------------------YSKEFE 2885

  Fly   392 KEMFL----AAAAAQHC-------GFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQ 445
            .|..:    .::.|..|       |..|...||       |.|.||.||.:|:.|.|..|:.|:.
Frog  2886 NEGMVDYSETSSLADPCSPSPGASGSAGKSGED-------RPGQKRFRTQMTNLQLKLLKSCFND 2943

  Fly   446 SPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGGGSGSGRGT-------- 502
            ...|.....|.|..|.||..|||||||||.|||.||.:....::.|....:..|..|
Frog  2944 YRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKDKKSKLSMAKHFGINQTNYEGPKTECTLCGIK 3008

  Fly   503 --GNSSATDD----------KDT----NDKEDK----------CVKQELG--GDSSGYLGGLDST 539
              ...|..|.          ||.    .|||.:          ..:|||.  ..::..||
Frog  3009 YSARLSVRDHIFSQQHISKVKDAIGSQLDKEKEYFDPATVRQLMAQQELDRIKKANEVLG----- 3068

  Fly   540 FASQPLNP---------NLPFSPDDYPA 558
            .||||.|.         |||.:   |||
Frog  3069 LASQPQNVFDNPSLQALNLPAA---YPA 3093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	11/74 (15%)
		LIM	333..388	CDD:295319	10/100 (10%)
		Homeobox	427..480	CDD:278475	25/52 (48%)
zfhx3	XP_002937624.2	C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	718..735	CDD:275368
		C2H2 Zn finger	1365..1385	CDD:275368
		C2H2 Zn finger	1403..1423	CDD:275371
		C2H2 Zn finger	1431..1452	CDD:275371
		C2H2 Zn finger	1547..1569	CDD:275368
		C2H2 Zn finger	1598..1616	CDD:275368
		HOX	2122..2178	CDD:197696
		Homeobox	2222..2276	CDD:365835
		COG5576	2590..2717	CDD:227863	14/126 (11%)
		Homeobox	2624..2677	CDD:365835	1/52 (2%)
		Homeobox	2926..2979	CDD:365835	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910