DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and prrx2

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_002940803.1	Gene:	prrx2 / 100488907	XenbaseID:	XB-GENE-947362	Length:	248	Species:	Xenopus tropicalis

Alignment Length:	190	Identity:	52/190 - (27%)
Similarity:	81/190 - (42%)	Gaps:	31/190 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 GRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQR 484
            |::..:|.||...|.|.:..:..|:::..|...|||.||:...||...|||||||:|||.::.:|
Frog    90 GKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVSLSEARVQVWFQNRRAKFRRNER 154

  Fly   485 KAKQNGGSGGGSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNL 549
            ..               ..:.|||..|..:  :|...:|::...:|      ..|....|.|.|.
Frog   155 AM---------------LASRSATHLKSYS--QDTGAEQQVSPRAS------TLTPEYMPWNSNS 196

  Fly   550 PFSPDDYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLELQSTSSSGNQHSHSHSN 609
            .:|....|..|..:..:|.....|.|.      |||::  :|.|::...|.:|...|..|
Frog   197 NYSNASLPPYSPTTTATSTAPTQGVNM------ADSIA--SLRLKAKEFSLHQSQVSPVN 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319
		Homeobox	427..480	CDD:278475	23/52 (44%)
prrx2	XP_002940803.1	Homeobox	98..151	CDD:365835	23/52 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910