DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lmx1a and arx

DIOPT Version :9

Sequence 1:	NP_729801.1	Gene:	Lmx1a / 39406	FlyBaseID:	FBgn0052105	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_002933659.1	Gene:	arx / 100486727	XenbaseID:	XB-GENE-483940	Length:	536	Species:	Xenopus tropicalis

Alignment Length:	197	Identity:	55/197 - (27%)
Similarity:	75/197 - (38%)	Gaps:	68/197 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 LQKGEQFMLR----DGQLFCYRHDLEKEMFLAAAAAQHCGFVGLD-EEDLLRPRDGRRGPKRPRT 429
            |...|:.||.    ||:      |.|..:.|:|         |.| ||.:|     :|..:|.||
Frog   262 LSPKEELMLHSSDADGK------DGEDSVCLSA---------GSDSEEGML-----KRKQRRYRT 306

  Fly   430 ILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGG 494
            ..||.|.::.:.:|.::..|....||.||....|:...|||||||:|||.:|.::...|....|
Frog   307 TFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHAPG- 370

  Fly   495 GSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNPNL---PFSPDDY 556
                                               ..:.|.|.   ||.||.|.|   || |..:
Frog   371 -----------------------------------LPFPGPLS---ASHPLGPYLDASPF-PPHH 396

  Fly   557 PA 558
            ||
Frog   397 PA 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757
		LIM	333..388	CDD:295319	6/21 (29%)
		Homeobox	427..480	CDD:278475	22/52 (42%)
arx	XP_002933659.1	Homeobox	305..358	CDD:365835	22/52 (42%)
arx	XP_002933659.1	OAR	500..518	CDD:367680
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910